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3,5-Diiodo-L-tyrosine dihydrate

Name: 3,5-Diiodo-<SC>L</SC>-tyrosine dihydrate
Brand: SIGMA

≥98.0% (HPLC), suitable for ligand binding assays

Synonym(s):

3,5-diiodo-L-tyrosine hydrate (1:2)

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About This Item

Empirical Formula (Hill Notation):

C₉H₉I₂NO₃ · 2H₂O

CAS Number:

18835-59-1

Molecular Weight:

469.01

NACRES:

NA.26

PubChem Substance ID:

24893289

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

206-092-0

MDL number:

MFCD00016542

Beilstein/REAXYS Number:

2218691

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Properties

Product Name

3,5-Diiodo-L-tyrosine dihydrate, crystalline

assay

≥98.0% (HPLC)

Quality Level

200

form

crystalline

technique(s)

ligand binding assay: suitable

color

white

mp

200 °C (dec.) (lit.)

solubility

4 M NH₄OH in methanol: 50 mg/mL, clear, yellow-green

storage temp.

−20°C

SMILES string

N[C@@H](Cc1cc(I)c(O)c(I)c1)C(O)=O

InChI

1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1

InChI key

NYPYHUZRZVSYKL-ZETCQYMHSA-N

Description

Application

Substrate for the assay of halogenated tyrosine and thyroid hormone aminotransferase.[1] Intermediate in the biosynthesis and alternative pathways of metabolism of thyroid hormones.[2]

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This Item	D0629	93829	F4505
Sigma-Aldrich D0754 3,5-Diiodo-L-tyrosine dihydrate	Sigma-Aldrich D0629 3,5-Diiodo-L-thyronine	Sigma-Aldrich 93829 L-Tyrosine	Sigma-Aldrich F4505 m-Fluoro-DL-tyrosine
form crystalline	form powder	form powder or crystals	form powder
assay ≥98.0% (HPLC)	assay ≥99% (HPLC)	assay ≥99.0% (NT)	assay ≥98%
technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable
storage temp. −20°C	storage temp. −20°C	storage temp. -	storage temp. 2-8°C
color white	color white to off-white	color white	color white
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose.

Jana Frýdlová et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 863(1), 135-140 (2008-02-08)

The interaction of porcine pepsin A with immobilized derivatives of aromatic amino acids was investigated. Divinyl sulfone-activated Sepharose was used to immobilize N-acetyl-l-phenylalanine and 3,5-diiodo-l-tyrosine via their free carboxyl groups and l-tyrosine via its amino group. Immobilized l-tyrosine was iodinated

Chiral discrimination of D- and L-amino acids using iodinated tyrosines as chiral references: effect of iodine substituent.

Sangeeta Kumari et al.

Journal of the American Society for Mass Spectrometry, 18(8), 1516-1524 (2007-06-26)

L-Tyrosine and iodinated L-tyrosines, i.e., 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine, are successfully used as chiral references for the chiral discrimination of aliphatic, acidic, and aromatic amino acids. Chiral discrimination is achieved by investigating the collision-induced dissociation spectra of the trimeric complex [Cu(II)(ref)(2)(A)

Identification and quantitation of iodotyrosines and iodothyronines in hydrolysate of iodinated casein by capillary electrophoresis.

Yining Zheng et al.

Talanta, 69(1), 107-112 (2008-10-31)

In this paper, a new method for separation, identification and quantitation of iodotyrosines and iodothyronines [3-monoiodo-L-tyrosine (MIT), 3,5-diiodo-L-tyrosine (DIT), L-thyronine (T(0)), 3,5-diiodo-L-thyronine (T(2)), 3,5,3'-triiodo-L-thyronine (T(3)) and 3,3',5,5'-tetraiodo-L-thyronine (T(4))] was described by using capillary electrophoresis with photodiode-array ultraviolet-visible detection (CE-UV). The

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Global Trade Item Number

SKU	GTIN
D0754-10G	04061833558041

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