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D0629

3,5-Diiodo-L-thyronine

thyroid hormone analog

Synonym(s):

3,5-Diiodo-4-(4-hydroxyphenoxy)-L-phenylalanine, 3,5-T2, O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine

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About This Item

Empirical Formula (Hill Notation):
C15H13I2NO4
CAS Number:
1041-01-6
Molecular Weight:
525.08
UNSPSC Code:
41116107
NACRES:
NA.26
PubChem Substance ID:
24893248
EC Number:
213-867-7
Beilstein/REAXYS Number:
2707891
MDL number:
MFCD00064987
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Quality Level

200

assay

≥99% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

mp

255 °C

storage temp.

−20°C

SMILES string

N[C@@H](Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1)C(O)=O

InChI

1S/C15H13I2NO4/c16-11-5-8(7-13(18)15(20)21)6-12(17)14(11)22-10-3-1-9(19)2-4-10/h1-6,13,19H,7,18H2,(H,20,21)/t13-/m0/s1

InChI key

ZHSOTLOTTDYIIK-ZDUSSCGKSA-N

Biochem/physiol Actions

3,5-Diiodo-L-thyronine ((T(2)) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance.

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This Item
719536D0754T2877
3,5-Diiodo-L-thyronine thyroid hormone analog

Sigma-Aldrich

D0629

3,5-Diiodo-L-thyronine

3,3′-Diiodo-L-thyronine (T2) hydrochloride 98% (CP)

Sigma-Aldrich

719536

3,3′-Diiodo-L-thyronine (T2) hydrochloride

3,5-Diiodo-L-tyrosine dihydrate crystalline

Sigma-Aldrich

D0754

3,5-Diiodo-L-tyrosine dihydrate

3,3′,5-Triiodo-L-thyronine ≥95% (HPLC), powder

Sigma-Aldrich

T2877

3,3′,5-Triiodo-L-thyronine

form

powder

form

powder

form

crystalline

form

powder

technique(s)

ligand binding assay: suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

ligand binding assay: suitable

technique(s)

transfection: suitable

assay

≥99% (HPLC)

assay

98% (CP)

assay

≥98.0% (HPLC)

assay

≥95% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

mp

255 °C

mp

-

mp

200 °C (dec.) (lit.)

mp

234-238 °C (lit.)

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hcodes

H412

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ5652
MKCL2543
MKCB2257V
MKCB1817V
MKCB0274V

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Related Content

Maria Moreno et al.
Thyroid : official journal of the American Thyroid Association, 18(2), 239-253 (2008-02-19)
The processes and pathways mediating the intermediary metabolism of carbohydrates, lipids, and proteins are all affected by thyroid hormones (THs) in almost all tissues. Particular attention has been devoted by scientists to the effects of THs on lipid metabolism. Among
Roberto Mangiullo et al.
Biochimica et biophysica acta, 1797(2), 233-240 (2009-11-03)
Besides triiodothyronine (T3), 3,5-diiodo-L-thyronine (T2) has been reported to affect mitochondrial bioenergetic parameters. T2 effects have been considered as independent of protein synthesis. Here, we investigated the effect of in vivo chronic T2 administration to hypothyroid rats on liver mitochondrial
Alessio Rochira et al.
Biochimica et biophysica acta, 1831(12), 1679-1689 (2013-08-21)
Thyroid hormone 3,5,3'-triiodo-l-thyronine (T3) is known to affect cell metabolism through both the genomic and non-genomic actions. Recently, we demonstrated in HepG2 cells that T3 controls the expression of SREBP-1, a transcription factor involved in the regulation of lipogenic genes.
View All Related Papers

Global Trade Item Number

SKUGTIN
D0629-5G04061832416076
D0629-500MG04061833557921

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