This product has not been tested in-house for this application, so a recommendation cannot be provided. Empirical testing based on a literature search may be necessary.
G6423
Gemcitabine hydrochloride
≥98% (HPLC), powder, deoxycytidine analog
Gemcitabine hydrochloride
1 of 1 reviewers received a sample product or took part in a promotion
Synonym(s):
2′-Deoxy-2′,2′-difluorocytidine; dFdC, Gemzar (Lilly), LY-188011, dFdC, dFdCyd
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About This Item
Empirical Formula (Hill Notation):
C9H11F2N3O4 · HCl
CAS Number:
Molecular Weight:
299.66
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated, protect from light
Pricing and availability is not currently available.
Product Name
Gemcitabine hydrochloride, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
solubility
H2O: ≥10 mg/mL
originator
Eli Lilly
storage temp.
room temp
SMILES string
Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
InChI
1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
InChI key
OKKDEIYWILRZIA-OSZBKLCCSA-N
Gene Information
General description
Gemcitabineis a pyrimidine nucleoside analog of deoxycytidine. It exhibits anticancereffects against various cancers.[1]
Application
Gemcitabinehydrochloride has been used as a chemotherapeutic agent to study its effects onthe human pancreatic adenocarcinoma cell line[2]It has been used as a chemotherapeutic to study its resistance inpancreatic stellate cells (PSCs)[3]It has also been used to study its effects on patient-derivedxenograft (PDX) organoids.[4]
Biochem/physiol Actions
Gemcitabine is a widely used antineoplastic agent and antimetabolite.
Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form powder | form - | form - | form powder |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 300 |
| storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition desiccated, protect from light | storage condition - | storage condition - | storage condition - |
| originator Eli Lilly | originator - | originator - | originator - |
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signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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welche maximalen Gemcitabinkonzentrationen werden für in-vitro-Modelle in PDAC-Zelllinien empfohlen? Die Angaben in der Literatur sind teilweise stark voneinander abweichend
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Wie können Aliquotes (in NaCl) am besten gelagert werden? Wäre eine Lagerung bei -20°C bedenkenlos über einen längeren Zeitraum möglich?
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This product can be stored in aliquots and frozen at -20°C. Stock solutions are stable for up to 6 months at -20°C.
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