C6019 is supplied in powder form. It is soluble in Chloroform at 50.0 - 52.0 mg/ml. But the information on the absorption molecular coefficient of clotrimazole is currently unavailable. However, I conducted an extensive literature search and found some relevant information. Clotrimazole showed absorption maxima (λ max) at 263 nm, and linearity was obtained by concentration versus absorbance for clotrimazole with a correlation coefficient of r = 0.999.
C6019
Clotrimazole
98.5-100.5% (dry basis), powder, Ca²⁺-activated K⁺ channels inhibitor
Synonym(s):
1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|
About This Item
Empirical Formula (Hill Notation):
C22H17ClN2
CAS Number:
Molecular Weight:
344.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
245-764-8
MDL number:
Form:
powder
Quality level:
Pricing and availability is not currently available.
Product Name
Clotrimazole,
form
powder
Quality Level
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes, protein synthesis | interferes
originator
Schering Plough
SMILES string
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
InChI
1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChI key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
Gene Information
human ... ABCB1(5243), CYP17A1(1586), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)
General description
Chemical structure: imidazole
Application
Clotrimazole has been used:
- to study the upregulation of the gene ERG11 that codes for an azole target enzyme lanosterol demethylase, in Candida species, upon treatment with azole antibiotics[1]
- to study the development of resistance in Candida species isolated from patients undergoing prolonged antifungal treatment[2]
- to induce stress granules via mitochondrial stress[3][4]
- for the inhibition of in vitro formation of high density sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB)[5]
- to inhibit cytochrome P450 enzyme in cell cultures[6]
Biochem/physiol Actions
Clotrimazole is a specific inhibitor of Ca2+-activated K+ channels.[7] It is an antifungal azole. Clotrimazole is a derivative of imidazole and has similar antimicrobial action and activity to ketoconazole.[8] It inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
1 of 1
This Item | |||
|---|---|---|---|
| form powder | form - | form - | form solid |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level - |
| originator Schering Plough | originator - | originator - | originator - |
| antibiotic activity spectrum fungi | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| mode of action cell membrane | interferes, protein synthesis | interferes | mode of action - | mode of action - | mode of action - |
| Gene Information human ... ABCB1(5243), CYP17A1(1586), CYP3A4(1576) | Gene Information - | Gene Information - | Gene Information - |
Still not finding the right product?
Explore all of our products under Clotrimazole
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Nancy Kedersha et al.
The Journal of cell biology, 169(6), 871-884 (2005-06-22)
Stress granules (SGs) are cytoplasmic aggregates of stalled translational preinitiation complexes that accumulate during stress. GW bodies/processing bodies (PBs) are distinct cytoplasmic sites of mRNA degradation. In this study, we show that SGs and PBs are spatially, compositionally, and functionally
A Shartava et al.
American journal of hematology, 62(1), 19-24 (1999-09-01)
Clotrimazole, a specific inhibitor of the Ca(2+) activated potassium (Gardos) channel, and the antioxidant N-acetylcysteine were found to inhibit the in vitro formation of high-density sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB). The CDNB induced leakage of K(+) can
Monica Kam Draskau et al.
Toxicology and applied pharmacology, 422, 115554-115554 (2021-04-29)
Clotrimazole is a non-prescription and broad-spectrum antifungal drug sold under brand names such as Canesten® and Lotrimin®. It is used to treat different types of fungal infections, from oral thrush to athlete's foot and vaginal mycosis. The level of exposure
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C6019-25G | 04061833503041 |
| C6019-5G | 04061833503058 |
| C6019-100G | 04061835374724 |
-
Please provide the absorption molecular coefficient of clotrimazole and the solvent used to quantify my clotrimazole solutions.
1 answer-
Helpful?
-