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42867

Dextran sulfate sodium salt

Mr ~40,000

Synonym(s):

DSS Dextran Sulfate Sodium

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About This Item

NACRES:
NA.25
UNSPSC Code:
12352201
Pricing and availability is not currently available.
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form

powder

Quality Level

100

mol wt

Mr ~40,000

technique(s)

tissue culture: suitable

loss

≤10% loss on drying

color

white to off-white

useful pH range

6.0-8 (10 g/L)

mp

(Decomposes on heating.)

solubility

water: soluble

suitability

suitable for component for culture media

storage temp.

room temp

General description

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Application

Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.

Biochem/physiol Actions

Treatment with dextran sulfate sodium triggers development of colitis in mice and rats by binding to medium-chain-length fatty acids present in the colon and inducing inflammation. [1]

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

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This Item
5122775027RES2029D-A7
Dextran sulfate sodium salt Mr ~40,000

Sigma-Aldrich

42867

Dextran sulfate sodium salt

Dextran sulfate sodium salt Mw 7,000-20,000

Sigma-Aldrich

51227

Dextran sulfate sodium salt

Dextran sulfate sodium salt

Sigma-Aldrich

75027

Dextran sulfate sodium salt

Dextran sulfate sodium salt

SAFC

RES2029D-A7

Dextran sulfate sodium salt

technique(s)

tissue culture: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | mammalian: suitable

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

300

solubility

water: soluble

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

solubility

-

suitability

suitable for component for culture media

suitability

-

suitability

-

suitability

suitable for manufacturing use

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

-

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000553391
0000553391
BCCP1894
BCCN9431
BCCN5478

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Li Cao et al.
International immunopharmacology, 72, 264-274 (2019-04-21)
Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To
Hamed Laroui et al.
PloS one, 7(3), e32084-e32084 (2012-03-20)
Inflammatory bowel diseases (IBDs), primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model. DSS induces in vivo but not in vitro intestinal
Andrey V Markov et al.
Molecules (Basel, Switzerland), 25(10) (2020-05-28)
Semi-synthetic triterpenoids, bearing cyano enone functionality in ring A, are considered to be novel promising therapeutic agents with complex inhibitory effects on tissue damage, inflammation and tumor growth. Previously, we showed that the cyano enone-containing 18βH-glycyrrhetinic acid derivative soloxolone methyl
View All Related Papers

Global Trade Item Number

SKUGTIN
42867-5G04061832104942
42867-25G04061832104935
42867-100G04061835541331

Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Does DDS (Dextran Sodium Sulfate) come in a USP grade for a animal studies?

    1 answer

    1. Unfortunately, there is no pharmaceutical grade Dextran Sodium Sulfate available at this time. This product is not tested for use in animal models. It would be up to the researcher to determine suitability.

      Helpful?

  4. Hello! I want to know if you can autoclave water with 4% of dextran sulfate sodium (DSS) without decomposing the DSS.

    1 answer

    1. The solubility of dextran sulfates is tested at 100 mg/mL in water. Clear solutions are obtained. Buffered aqueous dextran sulfate solutions can be sterilized by autoclaving at 110-115 °C for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. Dextran sulfate has a higher affinity for calcium ions than for sodium ions. The calcium salt of dextran sulfate is insoluble. The free acid (hydrogen) form of dextran sulfate is extremely acidic and autohydrolyzes rapidly in solution and as a powder.

      More information can be found here: https://www.sigmaaldrich.com/technical-documents/protocol/protein-biology/protein-pulldown/dextran-sulfate

      Helpful?

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