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Poloxamer 407

Name: Poloxamer 407
Brand: SIGMA

purified, non-ionic

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

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About This Item

CAS Number:

9003-11-6

UNSPSC Code:

12352104

NACRES:

NA.25

MDL number:

MFCD00082049

Pricing and availability is not currently available.

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Properties

Quality Segment

100

form

powder

quality

purified

impurities

≤1.0% water

pH

5.0-7.5

solubility

soluble, clear, colorless

cation traces

Al: ≤5 mg/kg, As: ≤0.05 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤50 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤1000 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

UV absorption

λ: 260 nm A_max: ≤0.3, λ: 280 nm A_max: ≤0..2

suitability

no residue for filter test

storage temp.

2-8°C

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

General description

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Application

Poloxamer 407 has been used:

as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
for VLDL secretion assay in mice
to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

Biochem/physiol Actions

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

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1 of 1

This Item	P2164030	62035	1.37112
Sigma-Aldrich 16758 Poloxamer 407	P2164030 Poloxamer 407	Sigma-Aldrich 62035 Poloxamer 407	SAFC 1.37112 Poloxamer 188
suitability no residue for filter test	suitability -	suitability -	suitability -
form powder	form -	form powder	form solid
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -	storage temp. 2-25°C
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 500
cation traces Al: ≤5 mg/kg, Ba: ≤5 mg/kg, Ca: ≤50 mg/kg, Co: ≤5 mg/kg, Cu: ≤5 mg/kg, K: ≤1000 mg/kg, Mg: ≤5 mg/kg, Mo: ≤5 mg/kg, Ni: ≤5 mg/kg, Sr: ≤5 mg/kg, As: ≤0.05 mg/kg, Cd: ≤5 mg/kg, Fe: ≤5 mg/kg, Mn: ≤5 mg/kg, Pb: ≤5 mg/kg, Bi: ≤5 mg/kg, Li: ≤5 mg/kg, Zn: ≤5 mg/kg, Cr: ≤5 mg/kg, Na: ≤50 mg/kg	cation traces -	cation traces -	cation traces -
impurities ≤1.0% water	impurities -	impurities ≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤0.75% water, ≤1 ppm ethylene oxide, ≤2 ppm arsenic traces, ≤20 ppm heavy metals, ≤5 ppm dioxan, ≤5 ppm propylene oxide, 50-125 ppm butylhydroxytoluene	impurities -

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Predicting Silk Fiber Mechanical Properties through Multiscale Simulation and Protein Design.

Nae-Gyune Rim et al.

ACS biomaterials science & engineering, 3(8), 1542-1556 (2017-10-03)

Silk is a promising material for biomedical applications, and much research is focused on how application-specific, mechanical properties of silk can be designed synthetically through proper amino acid sequences and processing parameters. This protocol describes an iterative process between research

Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis.

Camila S Freitas et al.

Parasitology research, 120(1), 321-335 (2020-11-17)

Treatment for visceral leishmaniasis (VL) is hampered mainly by drug toxicity, their high cost, and parasite resistance. Drug development is a long and pricey process, and therefore, drug repositioning may be an alternative worth pursuing. Cardenolides are used to treat

Origin and Function of Stress-Induced IL-6 in Murine Models.

Hua Qing et al.

Cell, 182(2), 372-387 (2020-07-02)

Acute psychological stress has long been known to decrease host fitness to inflammation in a wide variety of diseases, but how this occurs is incompletely understood. Using mouse models, we show that interleukin-6 (IL-6) is the dominant cytokine inducible upon

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Global Trade Item Number

SKU	GTIN
I6758-1G	04061835367078
I6758-10G	04061835367061
I6758-5G	04061835367085
420290-5GM	04055977210828
420322-10GM	07790788055622
420291-1GM	04055977210835
420291-5GM	07790788050108
420322-500GM	07790788050153
70527-3	07790788052690
420322-100GM	07790788050146
420322-1GM	04055977210552
420322-25GM	07790788057817
420322-5GM	04055977210620
16758-250G	04061838749628
I1284-5ML	04061833847640
71300-3	07790788053185
71300-4	04055977253191
70235-4	04055977258585
69450-3	04055977274332
70837-3	04055977272574
70836-3	04055977272550

Questions

1–4 of 4 Questions

Anonymous

10 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  10 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
Anonymous

2 years ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  2 years ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
  Helpful?
Anonymous

2 years ago

What does the number in poloxamer-407, 105, 108, etc. stand for?

1 answer
1. Technical Support
  
  2 years ago
  
  The numeric suffix in various forms of Poloxamers refers to the mass per mole of polyoxypropylene and the percentage of polyoxyethylene present in that specific compound.
  
  Helpful?
3 years ago

In poloxamer-407,105, 108 etc. This number stands for?

1 answer
1. Technical Support
  
  3 years ago
  
  Poloxamers are block co-polymers that have a basic structure of one central polyoxypropylene core adjoined to two polyoxyethylene side blocks or chains. The numeric suffix designated in various forms of Poloxamers is in reference to the mass per mole of polyoxypropylene and the percentage of polyoxyethylene present within that specific compound.
  See the link below for additional information. Examples can be found in Table 1 on page 2.
  https://nmr.oxinst.com/assets/uploads/MagRes/App%20Notes/X-Pulse/App_Note_3_Poloxamer_Oct_2019.pdf
  
  Helpful?

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