Each vial contains approximately 2.5 mg protein. The minimum protein concentration is 2.5 mg/mL. A survey of recent lots indicates a consistent concentration of 5.0 mg/mL. The minimum activity of this enzyme is 1 unit per milligram and varies considerably from lot to lot. This value is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot-specific Certificate:
https://www.sigmaaldrich.com/product/sigma/m7441#product-documentation
M7441
Monoamine Oxidase B human
recombinant, expressed in baculovirus infected BTI insect cells
Synonym(s):
MAO-B
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About This Item
Recombinant:
expressed in baculovirus infected BTI insect cells
Pricing and availability is not currently available.
recombinant
expressed in baculovirus infected BTI insect cells
Quality Segment
form
liquid
enzyme activity
≥1 U/mg
packaging
vial of ~2.5 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MAOB(4129)
General description
Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs.
Application
Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression. [1]
Monoamine Oxidase B has been used in a study to assess the effect of age in 23 different regions of the human brain. It has also been used in a study to determine the specific locations of monoamine oxidase in the human brain. [2]
Biochem/physiol Actions
MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.
Other Notes
kynuramine deamination activity: One unit will deaminate 1 nanomole of kynuramine per minute at pH 7.4 at 37 deg C.
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This Item | |||
|---|---|---|---|
| Gene Information human ... MAOB(4129) | Gene Information human ... MAOB(4129) | Gene Information human ... MAOB(4129) | Gene Information human ... MAOA(4128) |
| recombinant expressed in baculovirus infected BTI insect cells | recombinant - | recombinant - | recombinant expressed in baculovirus infected BTI insect cells |
| form liquid | form liquid | form buffered aqueous solution | form liquid |
| storage temp. −70°C | storage temp. −20°C | storage temp. −20°C | storage temp. −70°C |
| shipped in dry ice | shipped in wet ice | shipped in wet ice | shipped in dry ice |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Related Content
Datasheet
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M7441-5X1VL | 04061832730981 |
| M7441-1VL | 04061834062059 |
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