Solution stability has not been determined for this product, however commercial and pharmaceutical preparations are cited as being stable at room temperature for up to 18 months, protected from light. Folic acid is also a component of most of the classical DMEM media formulations, for example D5546. These products are also assigned a shelf life of 18 months, but are stored at 2 - 8 deg. C. Storing at -20 deg. C may or may not extend the shelf life. There is a possibility that the freeze/thaw process may result in precipitation and may be detrimental.
F8758
Folic acid
BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%
Synonym(s):
Pterylmonoglutamic acid, PteGlu, Pteroyl-L-glutamic acid, Vitamin M
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About This Item
Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
Molecular Weight:
441.40
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
34058014
UNSPSC Code:
12352205
EC Number:
200-419-0
MDL number:
Beilstein/REAXYS Number:
100781
Pricing and availability is not currently available.
biological source
synthetic
Quality Level
product line
BioReagent
assay
≥97%
form
powder
mol wt
Mw 441.40 g/mol
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable
color
dark yellow
solubility
1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange
storage temp.
room temp
SMILES string
NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
InChI
1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChI key
OVBPIULPVIDEAO-LBPRGKRZSA-N
General description
Folic acid (FA)/pterylmonoglutamic acid helps to block neural tube defects (NTDs).
Application
Folic acid has been used:
- to study the role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
- in cells and treatments
- in perforin gene targeting using the CRISPR/Cas gene editing approach
Biochem/physiol Actions
A nutritional delivery form of folate. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells.
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This Item | |||
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| technique(s) cell culture | insect: suitable, cell culture | plant: suitable, cell culture | mammalian: suitable | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable | technique(s) - | technique(s) - |
| biological source synthetic | biological source - | biological source synthetic (organic) | biological source - |
| assay ≥97% | assay - | assay 97.0-102.0% dry basis | assay - |
| form powder | form solid | form solid | form - |
| solubility 1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange | solubility - | solubility - | solubility - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. - | storage temp. - |
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Storage Class
11 - Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
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Product Information Sheet
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| F8758-25G | 04061833620977 |
| F8758-5G | 04061833621011 |
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Is it better to store folic acid (Product No. F8758) solution at RT or -20'C? Also, how long is it stable as a solution for at recommended temperature?
1 answer-
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Is Product No. F8758, Folic Acid, tested for endotoxins?
1 answer-
No, Product No. F8758 has not been tested for endotoxins. This product has, however, been tested for use in mammalian cell culture and insect cell culture.
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What is the solubility of folic acid (Product No. F8758)?
1 answer-
Product No. F8758 is soluble in 1 M NaOH (50 mg/mL). The free acid is only slightly soluble in water (0.01 mg/mL at 0 °C), and is insoluble in aqueous solutions below pH 5. It is soluble in sodium bicarbonate or sodium hydroxide solutions.
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What is the stability of folic acid (Product No. F8758) once in solution?
1 answer-
This product is photolabile and is inactivated by UV light. Alkaline solutions are reasonably stable in the dark, but heating will destroy both alkaline and acidic solutions.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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