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C0158

L-Carnitine inner salt

≥98%

Synonym(s):

(−)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate, Vitamin BT

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About This Item

Linear Formula:
(CH3)3N+CH2CH(OH)CH2COO-
CAS Number:
541-15-1
Molecular Weight:
161.20
NACRES:
NA.79
PubChem Substance ID:
24892238
UNSPSC Code:
12352209
EC Number:
208-768-0
MDL number:
MFCD00038747
Beilstein/REAXYS Number:
4292315
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Product Name

L-Carnitine inner salt, synthetic, ≥98%

biological source

synthetic

Quality Level

200

assay

≥98%

form

powder

color

white

mp

197-212 °C (lit.)

application(s)

cell analysis
detection

SMILES string

C[N+](C)(C)C[C@H](O)CC([O-])=O

InChI

1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1

InChI key

PHIQHXFUZVPYII-ZCFIWIBFSA-N

Application

L-Carnitine inner salt has been used as a component of an assay medium for Seahorse XF mitochondrial stress assay. It has also been orally administered to tumor-bearing mice, in order to study its effect on the regulation of peroxisome proliferator-activated receptor and thereby to analyse liver inflammatory response.

Biochem/physiol Actions

Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.
Carnitine biosynthesized from lysine. Carnitine facilitates fatty acid transport into the mitochondrial compartment. In skeletal and cardiac muscle tissue it acts as a metabolic cofactor. Carnitine might be associated with the energy production from branched chain amino acids.

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This Item
C0283C9500A1509
L-Carnitine inner salt synthetic, ≥98%

Sigma-Aldrich

C0158

L-Carnitine inner salt

L-Carnitine hydrochloride synthetic, ≥98%

Sigma-Aldrich

C0283

L-Carnitine hydrochloride

(±)-Carnitine hydrochloride ≥98% (TLC)

Sigma-Aldrich

C9500

(±)-Carnitine hydrochloride

Acetyl-DL-carnitine hydrochloride

Sigma-Aldrich

A1509

Acetyl-DL-carnitine hydrochloride

form

powder

form

powder

form

powder

form

powder

assay

≥98%

assay

≥98%

assay

≥98% (TLC)

assay

>98% (TLC)

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

color

white

color

white

color

white

color

white

mp

197-212 °C (lit.)

mp

142 °C

mp

-

mp

-

biological source

synthetic

biological source

synthetic

biological source

-

biological source

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7514V
WXBF5664V
WXBF3981V
WXBF4448V
WXBF2188V

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Sunil K Panchal et al.
Food & function, 6(8), 2496-2506 (2015-07-21)
Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. These impairments are associated with the development of cardiovascular disease and non-alcoholic fatty liver disease. Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular
L-carnitine ameliorates the liver inflammatory response by regulating carnitine palmitoyltransferase I-dependent PPAR? signaling
Fang Jiang
Molecular Medicine Reports, 13(2) (2015)
Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles
Rui Li
The Journal of Physiology, 594(24), 7197-7213 (2016)
View All Related Papers

Global Trade Item Number

SKUGTIN
C0158-100G04061833450246
C0158-5G04061835366392
C0158-1G04061833450253
C0158-25G04061833450260

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Hello, After dissolving the product in water, I want to ask about the storage conditions to ensure the stability of the product L-carnitine inner salt, product number C0158.

    1 answer

    1. The solution stability of this product has not been determined. It is recommended to prepare solutions fresh before use.

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