The solution stability of this product has not been determined. However, the 10% Lactic Acid solution in water, product number 63325, is a sterile filtered solution that has an assigned shelf life of 2 years when stored at 2-8°C. Other sources indicate prepared solutions of Lactic Acid Sodium may also be stored for 1 year at -80°C and 1 month at -20°C. Please note this information has not been validated.
L7022
Sodium L-lactate
~98%
Synonym(s):
(S)-2-Hydroxypropionic acid sodium salt, L-Lactic acid sodium salt, Sarcolactic acid sodium salt
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About This Item
Empirical Formula (Hill Notation):
C3H5NaO3
CAS Number:
Molecular Weight:
112.06
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
212-762-3
Beilstein/REAXYS Number:
4567087
MDL number:
Pricing and availability is not currently available.
biological source
synthetic (chemical)
Quality Level
assay
~98%
form
powder or crystals
color
white to faint yellow
mp
163-165 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
[Na+].C[C@H](O)C([O-])=O
InChI
1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1/t2-;/m0./s1
InChI key
NGSFWBMYFKHRBD-DKWTVANSSA-M
General description
Sodium L-lactate, an organic acid derived from L-lactic acid, naturally occurs in the body, contributing to pH regulation, acid-base equilibrium, and various physiological processes, including energy metabolism through the Cori cycle. Its versatile properties extend to antimicrobial action by creating an acidic environment that inhibits harmful bacterial growth. In metabolic pathways, Sodium L-lactate exhibits efficient conversion for energy production, potentially surpassing glucose uptake in certain instances, utilizing fatty acids as an alternative fuel source, and stimulating mitochondria for enhanced ATP production, indicating a role in optimizing cellular energy efficiency. Moreover, research suggests neuroprotective capabilities, safeguarding neuronal cells from high-fat diet-induced death and addressing potential links to obesity-related neurodegenerative issues.
This multifaceted nature of Sodium L-lactate positions it as a valuable molecule for research in cellular metabolism, neuroprotection, antimicrobial, and nutritional science, where its diverse properties, including efficient energy conversion, neuroprotective effects, and potent antimicrobial activity contribute to a deeper understanding across these scientific domains.
This multifaceted nature of Sodium L-lactate positions it as a valuable molecule for research in cellular metabolism, neuroprotection, antimicrobial, and nutritional science, where its diverse properties, including efficient energy conversion, neuroprotective effects, and potent antimicrobial activity contribute to a deeper understanding across these scientific domains.
Application
Sodium L-lactate has been used:
- as a medium supplement and cell fuel source for human mammary epithelial cell line(MCF10A) and dendritic cell culture
- as a gluconeogenic substrate in hepatic glucose production assay in primary hepatocytes
- in the glucose production medium for glucose production assay in human embryonic kidney (HEK293T) cells
- as a standard for calibration in lactate assay in bone marrow-derived macrophages
Biochem/physiol Actions
L-lactate is produced from pyruvate by the enzyme lactate dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells.
Features and Benefits
Versatile and adaptable for a wide variety of laboratory and research applications
Other Notes
For additional information on our range of Biochemicals, please complete this form.
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This Item | |||
|---|---|---|---|
| assay ~98% | assay ≥98% (titration) | assay ≥99.0% (NT) | assay ≥98% (CP) |
| biological source synthetic (chemical) | biological source - | biological source - | biological source - |
| solubility water: 50 mg/mL, clear, colorless | solubility water: 100 mg/mL, clear, colorless | solubility - | solubility - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder or crystals | form powder | form powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function
Galan-Davila AK, et al.
The Journal of Biological Chemistry, jbc-RA118 (2018)
Lactate is always the end product of glycolysis
Rogatzki MJ, et al.
Frontiers in Neuroscience, 9, 22-22 (2015)
Latent, Immunosuppressive Nature of Poly (lactic-co-glycolic acid) Microparticles
Allen RP, et al.
ACS biomaterials science & engineering, 4(3), 900-918 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L7022-5G | 04061835546541 |
| L7022-50G | 04061835546534 |
| L7022-10G | 04061835546527 |
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How stable is product once it is resuspended in solution? What are the recommended storage conditions and shelf life?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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