K1136

Ketorolac tris salt

synthetic (organic), ≥99%, COX inhibitor, crystalline

• Synonym(s): (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt, Toradol
• Empirical Formula (Hill Notation): C₁₅H₁₃NO₃ · C₄H₁₁NO₃
• CAS Number: 74103-07-4
• Molecular Weight: 376.40
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278503
• NACRES: NA.77
• MDL number: MFCD00887595

Properties

• Product Name: Ketorolac tris salt, ≥99%, crystalline
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥99%
• form: crystalline
• solubility: H₂O: soluble 15 mg/mL, clear, colorless to faintly yellow (stable at least one month at −20 °C.)
• storage temp.: room temp
• SMILES string: NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
• InChI: 1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
• InChI key: BWHLPLXXIDYSNW-UHFFFAOYSA-N
• Gene Information: human ... PTGS1(5742), PTGS2(5743)

Description

Application

Ketorolac has been used:

• as an intraperitoneal injection in mice to study the effect of ketorolac on expression of c-Fos (a human proto-oncogene) in ARC (arcuate nucleus of the hypothalamus) POMC (proopiomelanocortin) -EGFP (enhanced green fluorescent protein) neurons[1]
• to treat mice in order to show that this treatment does not prevent IL-1β-mediated inhibition of Agouti-related protein (AgRP) secretion from murine hypothalamic explants[2]
• as an analgesic medication to treat rats induced with acute inflammatory joint injury by injecting carrageenan into the ankle[3]

Biochem/physiol Actions

Ketorolac is a non-steroidal agent that possesses moderate anti-inflammatory activity and is also a potent analgesic. It shows superior analgesic efficacy to that of the opioid analgesics like morphine in patients with moderate to severe postsurgical pain. It inhibits prostaglandin synthesis and platelet aggregation induced by arachidonic acid and collagen.[4] It is a dual COX-1/COX-2 inhibitor.[5]

Disclaimer

Stable at least 2 years if stored at room temperature.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319,H335
• pcodes: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges