If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
I9657
Ionomycin from Streptomyces conglobatus
≥98% (HPLC)
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| Pack Size | SKU | Availability | Price |
|---|
About This Item
biological source
Streptomyces conglobatus
Quality Segment
assay
≥98% (HPLC)
solubility
acetonitrile: 10 mg/mL
antibiotic activity spectrum
Gram-positive bacteria
mode of action
cell membrane | interferes
storage temp.
−20°C
SMILES string
C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O
InChI
1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
InChI key
PGHMRUGBZOYCAA-ADZNBVRBSA-N
Application
- in magnesium-ionomycin treatment experiments
- as a supplement in calcium-free Dulbecco′s modified Eagle medium (DMEM) for ionophore treatment
- in the restimulation of peripheral blood mononuclear cells (PBMCs) to analyze cytokine production using flow cytometry (FCM)
- as a calcium ionophore to treat oocytes to perform intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)
Biochem/physiol Actions
1 of 1
This Item | |||
|---|---|---|---|
| mode of action cell membrane | interferes | mode of action cell membrane | interferes | mode of action cell membrane | interferes | mode of action DNA synthesis | interferes |
| antibiotic activity spectrum Gram-positive bacteria | antibiotic activity spectrum Gram-positive bacteria | antibiotic activity spectrum Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, neoplastics |
| Quality Level 300 | Quality Level 300 | Quality Level 300 | Quality Level 200 |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility acetonitrile: 10 mg/mL | solubility DMSO: 1 mM | solubility DMSO: 10 mg/mL, ethanol: soluble | solubility DMSO: 1.0 mg/mL |
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ppe
dust mask type N95 (US), Eyeshields, Gloves
Storage Class
10 - Combustible liquids
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| I9657-5MG | 04061833865750 |
| I9657-1MG | 04061833865743 |
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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