The product is not tested for solubility in water. However, various sources state that hesperidin is insoluble in water. For analytical purposes, this material is dissolved in pyridine at 50 mg/mL. Historical data indicates this compound is also soluble in DMSO at 30 mg/mL.
H5254
Hesperidin
≥80% (HPLC)
Synonym(s):
3′,5,7-Trihydroxy 4′-methoxyflavanone 7-rutinoside, Hesperetin 7-rhamnoglucoside, Hesperitin-7-rutinoside
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About This Item
Empirical Formula (Hill Notation):
C28H34O15
CAS Number:
Molecular Weight:
610.56
EC Number:
208-288-1
Beilstein/REAXYS Number:
75140
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
Pricing and availability is not currently available.
biological source
Citrus sinensis (L.) Osbeck
Quality Level
assay
≥80% (HPLC)
form
powder
color
yellow to faint beige
mp
250-255 °C (dec.) (lit.)
solubility
soluble, yellow to brown
storage temp.
2-8°C
SMILES string
COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2
InChI
1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
InChI key
QUQPHWDTPGMPEX-QJBIFVCTSA-N
Application
Studies of the behavior of hesperidin and hesperetin (the aglycone) with DMPC liposomes find the aglycone penetrates more deeply and binds more strongly to the "membrane." This may explain the better bioavailability of bioflavonoid aglycones in general.
Biochem/physiol Actions
Flavonoid phytochemical extracted from citrus species. It is the rhamnoglucoside (rutinoside) of hesperetin.
Other Notes
To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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This Item | |||
|---|---|---|---|
| biological source Citrus sinensis (L.) Osbeck | biological source - | biological source - | biological source - |
| assay ≥80% (HPLC) | assay ≥97.0% (HPLC) | assay ≥90.0% (HPLC) | assay - |
| solubility soluble, yellow to brown | solubility - | solubility - | solubility - |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 300 |
| form powder | form - | form powder | form - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Yomna S Mo'men et al.
Journal of biochemical and molecular toxicology, e22305-e22305 (2019-02-20)
Hesperidin is a flavanone glycoside that is found in the Citrus species and showed antioxidant, hepatoprotective as well as anticancer activity. This study investigated the effect of hesperidin on the PI3K/Akt pathway as a possible mechanism for its protective effect
Julia M Assini et al.
Current opinion in lipidology, 24(1), 34-40 (2012-12-21)
Citrus flavonoids are polyphenolic compounds with powerful biological properties. This review aims to summarize recent advances towards understanding the ability of citrus flavonoids to regulate lipid metabolism and other metabolic parameters relevant to the metabolic syndrome, type 2 diabetes and
Yong Yang et al.
European journal of medicinal chemistry, 58, 390-395 (2012-11-17)
We have identified a previously unknown function of the natural compound, hesperetin. Here, we demonstrate that this small molecular agent is able to inhibit the transforming growth factor-β (TGF-β) signaling pathway. Single-molecule force measurements and single-molecule fluorescence imaging show that
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H5254-25G | 04061835545544 |
| H5254-100G | 04061833797938 |
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Is the Hespiridin soluble in water
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Can this product be used in experimental animal models e.g Wistar rats via oral administration?
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This product is not tested for suitability for use in any animal model. So the recommendation would be to test it on a few rats in order to determine the suitability and the optimal dosage. Once that is established, it can be used in a larger scale experiment with more rats.
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