C6305

Clozapine

≥98% (TLC), powder, D₄-dopamine receptor antagonist

• Synonym(s): 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine
• Empirical Formula (Hill Notation): C₁₈H₁₉ClN₄
• CAS Number: 5786-21-0
• Molecular Weight: 326.82
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277892
• NACRES: NA.77
• MDL number: MFCD00153785
• Form: powder

Properties

• Product Name: Clozapine,
• form: powder
• Quality Segment: 300
• solubility: ethanol: 1 mg/mL, 0.1 M HCl: 30 mg/mL, DMSO: 4.8 mg/mL
• originator: Novartis
• SMILES string: CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
• InChI: 1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
• InChI key: QZUDBNBUXVUHMW-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HRH4(59340), HTR2A(3356), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR6(3362), HTR7(3363), KCNH1(3756), KCNH2(3757), UGT1A4(54657) ; rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Chrm1(25229), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2b(29581), Htr2c(25187), Htr3a(79246), Htr7(65032), Slc6a4(25553)

Description

Biochem/physiol Actions

Atypical antipsychotic compound. Selective antagonist for D₄-dopamine receptor. Antagonist at 5-HT_2A, 5-HT_2C, 5-HT₃, 5-HT₆, and 5-HT₇ serotonin receptors.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable