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Albendazole

Name: Albendazole
Brand: SIAL

analytical standard, ≥98%

Synonym(s):

Methyl 5-(propylthio)-2-benzimidazolecarbamate

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₅N₃O₂S

CAS Number:

54965-21-8

Molecular Weight:

265.33

NACRES:

NA.24

PubChem Substance ID:

329770859

UNSPSC Code:

41116107

EC Number:

259-414-7

MDL number:

MFCD00083232

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Properties

grade

analytical standard

Quality Level

100

assay

≥98%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CCCSc1ccc2[nH]c(NC(=O)OC)nc2c1

InChI

1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

InChI key

HXHWSAZORRCQMX-UHFFFAOYSA-N

Description

General description

Chemical structure: benzimidazole

Albendazole is a benzimidazole derivative used for the treatment of human gastrointestinal helmintiasis. It inhibits microtubule and blocks the glucose uptake that causes depletion of glycogen stores and lowering formation of adinosine triphosphate (ATP) in the larval and adult stages of susceptible parasite.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Albendazole may be used as a reference standard for the determination of albendazole and its major metabolites, albendazole sulphoxide and albendazole sulphone by high-performance liquid chromatography (HPLC) method in mice plasma.

Biochem/physiol Actions

Binds to tubulin and inhibits microtubule assembly.[1]

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This Item	PHR1281	1012553	A0325100
Supelco A4673 Albendazole	Supelco PHR1281 Albendazole	USP 1012553 Albendazole	A0325100 Albendazole
grade analytical standard	grade certified reference material, pharmaceutical secondary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
format neat	format neat	format neat	format neat
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) -
assay ≥98%	assay -	assay -	assay -
application(s) forensics and toxicology pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
Quality Level 100	Quality Level 300	Quality Level -	Quality Level -

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pictograms

GHS08,GHS09

signalword

Warning

hcodes

H361d,H373,H410

pcodes

P202 - P260 - P273 - P280 - P308 + P313 - P391

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Oral

target_organs

Adrenal gland,Blood,male reproductive organs,spleen

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The anthelmintic albendazole affects in vivo the dynamics and the detyrosination-tyrosination cycle of rat brain microtubules.

H D Solana et al.

Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 48(4), 199-205 (1999-01-23)

Albendazole (ABZ) is an anthelmintic benzimidazole drug widely used in human and veterinary medicine. ABZ has binding affinity to both mammalian and helminth parasite tubulin. In the current work, we have performed in vitro assays and in vivo experiments in

In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives.

Martin Spicher et al.

Antimicrobial agents and chemotherapy, 52(9), 3447-3450 (2008-07-16)

In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 microM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E. multilocularis metacestodes (200 mg/kg

Quantitative determination of albendazole and its main metabolites in plasma.

Garcia J J, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 723(1-2), 265-271 (1999)

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Global Trade Item Number

SKU	GTIN
A4673-10G	04061833374887

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