31640

4,4′-Diaminodiphenylmethane

analytical standard

• Synonym(s): DAPM, 4,4′-Methylenedianiline, MDA
• Empirical Formula (Hill Notation): C₁₃H₁₄N₂
• CAS Number: 101-77-9
• Molecular Weight: 198.26
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329753859
• EC Number: 202-974-4
• Beilstein/REAXYS Number: 474706
• MDL number: MFCD00007914

Properties

• grade: analytical standard
• Quality Level: 100
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• mp: 88-92 °C
• application(s): cleaning products; cosmetics; food and beverages; personal care
• format: neat
• SMILES string: Nc1ccc(Cc2ccc(N)cc2)cc1
• InChI: 1S/C13H14N2/c14-12-5-1-10(2-6-12)9-11-3-7-13(15)8-4-11/h1-8H,9,14-15H2
• InChI key: YBRVSVVVWCFQMG-UHFFFAOYSA-N

Description

General description

4,4′-Diaminodiphenylmethane (MDA) is an aromatic diamine, which finds industrial applications as a precursor in the manufacturing of polyurethane products, isocyanates, polyisocyanates, etc. It is also used as a hardener in the production of epoxy resins and elastomers.

4,4′-Diaminodiphenylmethane is a curing agent for epoxy resins. It is prepared from formaldehyde aniline when heated with aniline hydrochloride and aniline.

This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)

Application

4,4′-Diaminodiphenylmethane is used as an analytical reference standard for the quantification of the analyte in the following:

• Urine samples using gas-chromatography coupled to mass spectrometry (GC-MS).
• Hepatic microsomal incubation mixture from rabbits using high-performance liquid chromatography-plasma spray mass spectrometry (HPLC-PSP-MS), offline HPLC with fast atom bombardment mass spectrometry (FAB-MS) and fast atom bombardment tandem mass spectrometry (FAB-MS/MS).

It is reported to be used in the synthesis of amino modified multi-walled carbon nanotubes/polydimethylsiloxane, which serves as a coating for the stir bar sorptive extraction (SBSE) of phenols in environmental samples, followed by analysis using high performance liquid chromatography with ultraviolet detection (HPLC-UV).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety Information

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H301,H317,H341,H350,H370,H373,H410
• pcodes: P202 - P260 - P273 - P280 - P301 + P310 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 1B - Muta. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 1
• target_organs: Liver, Liver,eye - retina
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: 429.8 °F - closed cup
• flash_point_c: 221 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges