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Clotrimazole

Name: Clotrimazole
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₇ClN₂

CAS Number:

23593-75-1

Molecular Weight:

344.84

NACRES:

NA.24

PubChem Substance ID:

329749440

UNSPSC Code:

41116107

MDL number:

MFCD00057220

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Properties

grade

pharmaceutical primary standard

API family

clotrimazole

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4

InChI

1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

InChI key

VNFPBHJOKIVQEB-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Clotrimazole USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Clotrimazole and Betamethasone Dipropionate Cream
Clotrimazole Cream
Clotrimazole Lotion
Clotrimazole Lozenges
Clotrimazole Topical Solution
Clotrimazole Vaginal Inserts

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	C2430000	PHR1058	Y0000849
USP 1141002 Clotrimazole	C2430000 Clotrimazole	Supelco PHR1058 Clotrimazole	Y0000849 Clotrimazole for peak identification
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade pharmaceutical primary standard
manufacturer/tradename USP	manufacturer/tradename EDQM	manufacturer/tradename -	manufacturer/tradename EDQM
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
API family clotrimazole	API family clotrimazole	API family clotrimazole	API family clotrimazole

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pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H315,H319,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

pcodes

P264 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

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Synergistic activity of phenazines isolated from Pseudomonas aeruginosa in combination with azoles against Candida species.

S Nishanth Kumar et al.

Medical mycology, 52(5), 482-490 (2014-06-12)

Candidiasis infections are caused by yeasts from the genus Candida. The types of infection range from superficial to systemic. Treatment often requires antifungals such as the azoles; however, increased use of these drugs has led to the generation of yeasts

Clotrimazole: a review of its antifungal activity and therapeutic efficacy.

P R Sawyer et al.

Drugs, 9(6), 424-447 (1975-01-01)

Clotrimazole 2, a synthetic imidazole derivative, is primarily used locally in the treatment of vaginal and skin infections due to yeasts and dermatophytes. In vitro, it is most active against Candida spp., Trichophyton spp., Microsporum spp. and Malazzesia fuffur (Pityrosporon

Clotrimazole/betamethasone diproprionate: a review of costs and complications in the treatment of common cutaneous fungal infections.

H L Greenberg et al.

Pediatric dermatology, 19(1), 78-81 (2002-02-28)

The use of antifungal/corticosteroid combinations as topical therapy for dermatophytoses has been criticized as being less effective, more expensive, and the cause of more adverse cutaneous reactions than antifungal monotherapy. The combination of clotrimazole and betamethasone diproprionate (Lotrisone) is a

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Global Trade Item Number

SKU	GTIN
1141002-200MG	04061838701695

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