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Etodolac

Name: Etodolac
Brand: SIGMA

Synonym(s):

1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid, Etodolic acid, NSC 282126

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₁NO₃

CAS Number:

41340-25-4

Molecular Weight:

287.35

NACRES:

NA.77

PubChem Substance ID:

24278407

UNSPSC Code:

12352200

MDL number:

MFCD00133313

Quality level:

200

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Properties

Quality Level

200

originator

Wyeth

storage temp.

2-8°C

SMILES string

CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12

InChI

1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)

InChI key

NNYBQONXHNTVIJ-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Description

Biochem/physiol Actions

Non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX-1 and COX-2.

Features and Benefits

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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1 of 1

This Item	E2470000	1268706	SML0021
Sigma-Aldrich E0516 Etodolac	E2470000 Etodolac	USP 1268706 Etodolac	Sigma-Aldrich SML0021 PDI inhibitor 16F16
Quality Level 200	Quality Level -	Quality Level -	Quality Level 100
storage temp. 2-8°C	storage temp. -	storage temp. -	storage temp. 2-8°C
originator Wyeth	originator -	originator -	originator -
Gene Information human ... PTGS1(5742), PTGS2(5743)	Gene Information human ... PTGS2(5743)	Gene Information human ... PTGS2(5743)	Gene Information -

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

0000417146

0000404552

0000188584

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Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses.

Yael Goldfarb et al.

Annals of surgery, 253(4), 798-810 (2011-04-09)

Surgical procedures, including primary tumor resection, have been suggested to suppress immune competence and to promote postoperative infections and cancer metastasis. Catecholamines and prostaglandins were recently implicated in these processes, and in directly promoting tumor angiogenesis and invasion. To examine

Etodolac. A preliminary review of its pharmacodynamic activity and therapeutic use.

S Lynch et al.

Drugs, 31(4), 288-300 (1986-04-01)

Etodolac is a new non-steroidal agent (NSAID) with anti-inflammatory and analgesic activity. It has been studied in rheumatoid arthritis, osteoarthritis, and pain resulting from minor surgery. In the latter setting, etodolac is at least as effective as aspirin in terms

A review of the antiarthritic efficacy and safety of etodolac.

N Zvaifler

Clinical rheumatology, 8 Suppl 1, 43-53 (1989-03-01)

Etodolac (Lodine, Ramodar, Ultradol), an anti-inflammatory, analgesic agent, is the first of a new class of nonsteroidal anti-inflammatory drugs (NSAIDs), the pyranocarboxylic acids. A review of the literature on numerous clinical studies showed that etodolac (200 to 600 mg/day) is

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Global Trade Item Number

SKU	GTIN
E0516-50MG	04061832785356
E0516-10MG	04061833601143

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