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D6196

Dimebon dihydrochloride hydrate

≥98% (HPLC)

Synonym(s):

2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate, Dimebolin dihydrochloride hydrate, Dimeboline dihydrochloride hydrate, Dimebone dihydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C21H25N3 · 2HCl · xH2O
CAS Number:
97657-92-6
Molecular Weight:
392.37 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
329798824
UNSPSC Code:
12352200
MDL number:
MFCD17215933
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4

InChI

1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2

InChI key

QQHQMWVYYVVAOV-UHFFFAOYSA-N

Biochem/physiol Actions

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML2774SML0588T2705
Dimebon dihydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

D6196

Dimebon dihydrochloride hydrate

KDOAM25 hydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

SML2774

KDOAM25 hydrochloride hydrate

CP-94,253 dihydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0588

CP-94,253 dihydrochloride

Topotecan hydrochloride hydrate ≥98% (HPLC and enzymatic)

Sigma-Aldrich

T2705

Topotecan hydrochloride hydrate

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC and enzymatic)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

room temp

storage temp.

−20°C

solubility

H2O: ≥10 mg/mL

solubility

H2O: 2 mg/mL, clear

solubility

H2O: 15 mg/mL, clear

solubility

DMSO: ≥20 mg/mL

color

white to off-white

color

white to beige

color

white to beige

color

yellow

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
050M4626V
0000098325
0000098326
0000062748
0000062747

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Diana Duarte et al.
Biomolecules, 12(2) (2022-02-26)
Despite the progressive research and recent advances in drug therapy to treat solid tumours, the number of cases and deaths in patients with cancer is still a major health problem. Drug repurposing coupled to drug combination strategies has been gaining

Global Trade Item Number

SKUGTIN
D6196-5MG04061832981383
D6196-25MG04061832981376

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