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About This Item
Empirical Formula (Hill Notation):
C6H8ClN7O · HCl · 2H2O
CAS Number:
Molecular Weight:
302.12
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
Pricing and availability is not currently available.
grade
pharmaceutical primary standard
API family
amiloride
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl.O.O
InChI
1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
InChI key
LTKVFMLMEYCWMK-UHFFFAOYSA-N
General description
Amiloride hydrochloride is a photosensitive yellow powder used as a mild diuretic drug.[1]
Application
Amiloride hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Amiloride Hydrochloride and Hydrochlorothiazide Tablets
- Amiloride Hydrochloride Tablets
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
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This Item | |||
|---|---|---|---|
| manufacturer/tradename USP | manufacturer/tradename - | manufacturer/tradename EDQM | manufacturer/tradename USP |
| grade pharmaceutical primary standard | grade - | grade pharmaceutical primary standard | grade pharmaceutical primary standard |
| application(s) pharmaceutical (small molecule) | application(s) - | application(s) - | application(s) pharmaceutical (small molecule) |
| format neat | format - | format neat | format neat |
| API family amiloride | API family - | API family amiloride | API family amiloride |
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Novel molecular platforms for epithelial sodium channel (ENaC) modulators are claimed in the following six patents: WO2012035158(A1); WO2009074575(A2); WO2011028740(A1); WO2009150137(A2); WO2011079087(A1); WO2008135557(A1). These ENaC inhibitors may be used in blocking transepithelial sodium and consequently water absorption across airway epithelia. This
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Hypertonic saline (HS) inhalation therapy benefits cystic fibrosis (CF) patients [Donaldson SH, Bennet WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. N Engl J Med 354: 241-250, 2006; Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks
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In Dahl salt-sensitive rats (Dahl SS), glomerular capillary pressure increases in response to high salt intake and this is accompanied by significant glomerular injury compared with spontaneously hypertensive rats with similar blood pressure. Glomerular capillary pressure is controlled mainly by