Key Documents

Amikacin disulfate salt

Name: Amikacin disulfate salt
Brand: SIGMA

potency: 674-786 μg per mg (as amikacin base)

Synonym(s):

(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide disulfate, Antibiotic BB-K8 sulfate

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₄₃N₅O₁₃ · 2H₂SO₄

CAS Number:

39831-55-5

Molecular Weight:

781.76

UNSPSC Code:

51281632

NACRES:

NA.85

PubChem Substance ID:

24890586

EC Number:

254-648-6

Beilstein/REAXYS Number:

6172633

MDL number:

MFCD00167475

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Properties

biological source

synthetic

Quality Segment

200

form

powder or crystals

potency

674-786 μg per mg (as amikacin base)

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

InChI

1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1

InChI key

FXKSEJFHKVNEFI-GCZBSULCSA-N

Description

General description

Chemical structure: aminoglycoside

Application

Amikacin is an aminoglycoside antibiotic commonly used in the treatment of drug-resistant mycobacteria [1]. It is used to study organism-directed delivery of antibiotics as well as drug resistance .

Biochem/physiol Actions

Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Show Differences

1 of 1

This Item	A2324	K1876	A3650
Sigma-Aldrich A1774 Amikacin disulfate salt	Sigma-Aldrich A2324 Amikacin sulfate salt	Sigma-Aldrich K1876 Kanamycin disulfate salt from Streptomyces kanamyceticus	Sigma-Aldrich A3650 Amikacin hydrate
mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes
antibiotic activity spectrum Gram-negative bacteria, mycobacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma	antibiotic activity spectrum Gram-negative bacteria, mycobacteria
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder or crystals	form powder	form powder	form powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C
potency 674-786 μg per mg (as amikacin base)	potency -	potency ~650 μg per mg	potency -

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H317,H361fd

pcodes

P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313

Hazard Classifications

Repr. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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