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Nifedipine Nitrosophenylpyridine Analog

Name: Nifedipine Nitrosophenylpyridine Analog
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Dimethyl 2,6-dimethyl-4-(2-nitrosophenyl)-3,5-pyridinedicarboxylate

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₆N₂O₅

CAS Number:

50428-14-3

Molecular Weight:

328.32

NACRES:

NA.24

PubChem Substance ID:

329750560

UNSPSC Code:

41116107

MDL number:

MFCD22572715

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Properties

grade

pharmaceutical primary standard

API family

nifedipine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

O=C(OC)C1=C(C2=C(N=O)C=CC=C2)C(C(OC)=O)=C(C)N=C1C

InChI

1S/C17H16N2O5/c1-9-13(16(20)23-3)15(11-7-5-6-8-12(11)19-22)14(10(2)18-9)17(21)24-4/h5-8H,1-4H3

InChI key

MUZLTKGYFZENFW-UHFFFAOYSA-N

Description

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.

This product is provided as delivered and specified by the issuing Pharmacopoeia. For further information and support, including certificate/ product information sheets, please go to the website of the issuing Pharmacopoeia.

Application

Nifedipine Nitrosophenylpyridine Analog USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Nifedipine
Nifedipine Capsules
Nifedipine Extended-Release Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	1463870	N0750000	1463858
USP 1463701 Nifedipine Nitrosophenylpyridine Analog	USP 1463870 Nimodipine Related Compound A	N0750000 Nifedipine	USP 1463858 Nimodipine
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
manufacturer/tradename USP	manufacturer/tradename USP	manufacturer/tradename EDQM	manufacturer/tradename USP
format neat	format neat	format neat	format neat
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
API family nifedipine	API family nimodipine	API family nifedipine	API family nimodipine

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pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

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Certificates of Analysis (COA)

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NTP, the photoproduct of nifedipine, activates caffeine-sensitive ion channels in leech neurons.

Jürgen Schoppe et al.

Cell calcium, 33(3), 207-221 (2003-02-26)

Leech P neurons possess caffeine-sensitive ion channels in intracellular Ca(2+) stores and in the plasma membrane. The following results indicate that these channels are also activated by 2,6-dimethyl-4-(2-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (NTP), the photoproduct of the L-type Ca(2+) channel-blocker nifedipine:

Determination of 2,6-dimethyl-4-(2'-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethylester in nifedipine by derivative UV-spectrophotometry in bulk material and pharmaceutical forms.

G Carlucci et al.

Farmaco (Societa chimica italiana : 1989), 45(6 Suppl), 751-755 (1990-06-01)

A method for the determination of 2,6-dimethyl-4-(2'-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethylester in nifedipine (bulk material and pharmaceutical formulations) by second-derivative ultraviolet spectrophotometry is described. The procedure is simple and rapid and gives accurate and precise results.

Spin-trapping and antioxidant properties of illuminated and nonilluminated nifedipine and nimodipine in heart homogenate and model system.

V Misík et al.

Molecular pharmacology, 40(3), 435-439 (1991-09-01)

Nifedipine [1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic+ ++ acid dimethyl ester] and nimodipine [1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic+ ++ acid 2-methoxyethyl 1-methylethyl ester], incorporated into diheptanoylphosphatidylcholine liposomes, which were used as a drug carrier system, slightly inhibited lipid peroxidation (induced by tert-butylhydroperoxide and Fe2+) in rat heart homogenate. Illumination

Global Trade Item Number

SKU	GTIN
1463701-25MG	04061838736758

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