This is a compendial impurity standard product of the British Pharmacopoeia. This material is not isotopically labeled and is intended for use as a representative standard of the impurities known to be present in budesonide. A chromatogram of the current lot lists Budesonide epimers A & B, as well as Impurity D epimers 1 & 2. Please see the link below to access the supplier leaflet containing additional data:
https://www.pharmacopoeia.com/shop/products/1000014614
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About This Item
Empirical Formula (Hill Notation):
C25H34O6
CAS Number:
Molecular Weight:
430.53
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
Pricing and availability is not currently available.
grade
pharmaceutical primary standard
API family
budesonide
form
solid
shelf life
limited shelf life, expiry date on the label
manufacturer/tradename
BP
application(s)
pharmaceutical
pharmaceutical small molecule
format
mixture
storage temp.
−20°C
SMILES string
[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H]5OC(CCC)O[C@@]45C(=O)CO
InChI
1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
InChI key
VOVIALXJUBGFJZ-KWVAZRHASA-N
Gene Information
human ... NR3C1(2908)
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Budesonide impurity standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.
Also used in monographs such as:Budesonide Aqueous Nasal Spray
Also used in monographs such as:
Biochem/physiol Actions
Budesonide is a second generation glucocorticoid with low systemic absorption. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis, and inflammatory bowel disease. It inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein in primary human bronchial epithelial cells. Budesonide is currently in clinical trials for the prevention of lung cancer. It shows inhibitory effects on benzo[a]pyrene-induced carcinogenesis of the lung in mice.
Second generation glucocorticoid with low systemic absorption; anti-inflammatory agent; inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein.
Packaging
Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia
Other Notes
Sales restrictions may apply.
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This Item | |||
|---|---|---|---|
| grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard |
| manufacturer/tradename BP | manufacturer/tradename BP | manufacturer/tradename BP | manufacturer/tradename USP |
| application(s) pharmaceutical | application(s) pharmaceutical | application(s) pharmaceutical | application(s) pharmaceutical (small molecule) |
| shelf life limited shelf life, expiry date on the label | shelf life limited shelf life, expiry date on the label | shelf life limited shelf life, expiry date on the label | shelf life - |
| format mixture | format neat | format mixture | format neat |
| form solid | form solid | form solid | form - |
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - Skin Sens. 1 - STOT RE 1 Inhalation
target_organs
Adrenal gland
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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To whom it may concern, what do you mean exactly for Impurity standard? Is there any isotope present in the molecule, like a C-13 substitution for budesonide?
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