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T4069

JC-1

≥97% purity, solid

Synonym(s):

5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide, CBIC2(3)

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About This Item

Empirical Formula (Hill Notation):
C25H27Cl4IN4
CAS Number:
3520-43-2
Molecular Weight:
652.23
UNSPSC Code:
12171500
PubChem Substance ID:
24900193
NACRES:
NA.47
MDL number:
MFCD00188475
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Product Name

JC-1, powder or solid (Crystals)

assay

≥97%

Quality Segment

100

form

powder or solid (Crystals)

technique(s)

titration: suitable

color

faint red to very dark red

ε (extinction coefficient)

≥175000 at 511-517 nm in methanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[I-].CCN1C(=C\C=C\c2n(CC)c3cc(Cl)c(Cl)cc3[n+]2CC)/N(CC)c4cc(Cl)c(Cl)cc14

InChI

1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;/h9-15H,5-8H2,1-4H3;1H/q+1;/p-1

InChI key

FYNNIUVBDKICAX-UHFFFAOYSA-M

Application

The cyanine dye JC-1 has been used to determine mitochondrial transmembrane potential.
A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent (λex 520 nm) monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent (λem 596 nm ) "J-aggregates," which exhibit broad excitation and very narrow emission spectra. The ratio of red to green fluorescence of JC-1 is dependent only on membrane potential, and not influenced by mitochondrial size, shape, or density.

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This Item
SML3593PHL8916650636
JC-1 powder or solid (Crystals)

Sigma-Aldrich

T4069

JC-1

Hexachlorophene ≥95% (HPLC)

Sigma-Aldrich

SML3593

Hexachlorophene

I3,II8-Biapigenin phyproof® Reference Substance

PHL89166

I3,II8-Biapigenin

Paraquat dichloride-(rings-d8) hydrate PESTANAL®, analytical standard

Supelco

50636

Paraquat dichloride-(rings-d8) hydrate

technique(s)

titration: suitable

technique(s)

-

technique(s)

-

technique(s)

-

color

faint red to very dark red

color

white to beige

color

-

color

-

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

-

application(s)

-

application(s)

agriculture

form

powder or solid (Crystals)

form

powder

form

solid

form

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

assay

≥97%

assay

≥95% (HPLC)

assay

≥98.0% (HPLC)

assay

≥98.0% (HPLC)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB6031
MKCZ5582
MKCX9305
MKCX2204
MKCW5291

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Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion
Li L
Cell Death & Disease (2016)
Shumin Qin et al.
Frontiers in pharmacology, 10, 894-894 (2019-09-03)
Alcohol consumption affects gastric mucosa by multiple and complex mechanisms depending either by direct contact of ethanol or by indirect biological damage induced by its metabolite acetaldehyde. The present study aims at further investigating the mechanism of ethanol-induced gastric mucosa
Xianbin Cao et al.
Cellular signalling, 62, 109337-109337 (2019-06-08)
Radiation-induced tumor cells death is the theoretical basis of tumor radiotherapy. Death signaling disorder is the most important factor for radioresistance. However, the signaling pathway(s) leading to radiation-triggered cell death is (are) still not completely known. To better understand the
View All Related Papers

Global Trade Item Number

SKUGTIN
T4069-5MG04061837345500

Questions

  1. Mitochondria Staining Kit (CS0390)에 들어있는 1MG-JC-1 powder와 다른 제품인가요? 동일 농도로 DMSO이용해 녹였더니 Stock 색상이 다릅니다.

    1 answer

    1. Yes, the T4069, JC-1 product is also supplied in the Mitochndria Stain kit, CS0390. Both are prepared at 1 mg/mL in DMSO resulting in a red solution. Slight variations in color may be considered normal and the result of lot-to-lot variability. Marked differences in color should be discussed with Technical Service.

      Should this be the case, please navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquiries" under the Products Section and respond with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.

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