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Sodium taurodeoxycholate hydrate

Name: Sodium taurodeoxycholate hydrate
Brand: SIGMA

BioXtra, ≥97% (TLC)

Synonym(s):

2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate

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About This Item

Linear Formula:

C₂₆H₄₄NO₆SNa · xH₂O

CAS Number:

207737-97-1

Molecular Weight:

521.69 (anhydrous basis)

UNSPSC Code:

12161900

NACRES:

NA.25

PubChem Substance ID:

24899897

MDL number:

MFCD00149238

Beilstein/REAXYS Number:

3901204

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Properties

description

anionic

Quality Segment

200

product line

BioXtra

assay

≥97% (TLC)

mol wt

micellar avg mol wt 3100

aggregation number

impurities

≤0.002% Phosphorus (P), ≤0.1% Insoluble matter

CMC

1-4 mM (20-25°C)

solubility

H₂O: 0.5 M, clear, colorless to faintly yellow

anion traces

chloride (Cl^-): ≤0.5%, sulfate (SO₄^2-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.01%, Mg: ≤0.005%, NH₄⁺: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%

Description

General description

Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.

Application

Bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins.

Sodium tauroursodeoxycholate has been used in a study to assess short-term feedback regulation of bile salt uptake in rodent liver. [1] It has also been used in a study to investigate its potential to resolve endoplasmic reticulum (ER) stress in intestinal epithelial cells. [2] It is also used for isolation of membrane proteins including inner mitochondrial membrane proteins.

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This Item	T0875	T0266	G7132
Sigma-Aldrich T0557 Sodium taurodeoxycholate hydrate	Sigma-Aldrich T0875 Sodium taurodeoxycholate hydrate	Sigma-Aldrich T0266 Sodium tauroursodeoxycholate	Sigma-Aldrich G7132 Sodium glycocholate hydrate
assay ≥97% (TLC)	assay ≥95% (HPLC)	assay ≥95.0% (TLC)	assay ≥95% (TLC)
aggregation number 6	aggregation number 6	aggregation number -	aggregation number 1.9
CMC 1-4 mM (20-25°C)	CMC 1-4 mM (20-25°C)	CMC 4	CMC 13 mM (20-25°C)(lit.)
impurities ≤0.002% Phosphorus (P), ≤0.1% Insoluble matter	impurities -	impurities -	impurities -
mol wt micellar avg mol wt 3100	mol wt micellar avg mol wt 3100	mol wt 521.69 g/mol	mol wt micellar avg mol wt 900(lit.)
anion traces chloride (Cl^-): ≤0.5%, sulfate (SO₄^2-): ≤0.05%	anion traces -	anion traces -	anion traces -

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Structure-function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells.

Emanuel Berger et al.

Biochemical and biophysical research communications, 409(4), 610-615 (2011-05-25)

Inflammatory bowel diseases (IBD) are chronically relapsing and immune-mediated disorders of the gastrointestinal tract. Endoplasmic reticulum (ER) stress mechanisms in the epithelium have been demonstrated to be implemented into the pathogenesis of intestinal inflammation. Chemical chaperones have been demonstrated to

Short-term feedback regulation of bile salt uptake by bile salts in rodent liver.

Stefanie Mühlfeld et al.

Hepatology (Baltimore, Md.), 56(6), 2387-2397 (2012-07-19)

The sodium taurocholate cotransporting polypeptide (Ntcp) is the major bile salt uptake transporter at the sinusoidal membrane of hepatocytes. Short-term feedback regulation of Ntcp by primary bile salts has not yet been investigated in vivo. Subcellular localization of Ntcp was

Interpersonal Gut Microbiome Variation Drives Susceptibility and Resistance to Cholera Infection.

Salma Alavi et al.

Cell, 181(7), 1533-1546 (2020-07-08)

The gut microbiome is the resident microbial community of the gastrointestinal tract. This community is highly diverse, but how microbial diversity confers resistance or susceptibility to intestinal pathogens is poorly understood. Using transplantation of human microbiomes into several animal models

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Global Trade Item Number

SKU	GTIN
T0557-1G	04061835507450
T0557-5G	04061837335358
T0557-500MG	04061833503690

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