SML1795

Tenofovir

≥98% (HPLC), DNA chain terminator, powder

• Synonym(s): (R)-9-(2-Phosphonomethoxypropyl)adenine, (R)-PMPA
• Empirical Formula (Hill Notation): C₉H₁₄N₅O₄P
• CAS Number: 147127-20-6
• Molecular Weight: 287.21
• UNSPSC Code: 51111800
• PubChem Substance ID: 329826070
• NACRES: NA.77
• MDL number: MFCD00943794
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Tenofovir, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -20 to -26°, c = 0.5 in 1 M HCl
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: OP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(O)=O
• InChI: 1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
• InChI key: SGOIRFVFHAKUTI-ZCFIWIBFSA-N

Description

Biochem/physiol Actions

Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription.

Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. Tenofovir is an antiretroviral used for HIV treatment and prevention.

Tenofovir has a low oral bioavailability. Hence, it is available as a prodrug called tenofovir disoproxil fumarate. Once ingested, tenofovir disoproxil fumarate is hydrolyzed to tenofovir and phosphorylated. This is then incorporated into the viral DNA which leads to chain termination. Tenofovir is also effective against hepatitis B virus.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable