SML1323

NU6140

≥98% (HPLC)

• Synonym(s): 4-[[6-(Cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-benzamide
• Empirical Formula (Hill Notation): C₂₃H₃₀N₆O₂
• CAS Number: 444723-13-1
• Molecular Weight: 422.52
• NACRES: NA.77
• PubChem Substance ID: 329825785
• UNSPSC Code: 12352200
• MDL number: MFCD09264153
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(N(CC)CC)C1=CC=C(NC2=NC(NC=N3)=C3C(OCC4CCCCC4)=N2)C=C1
• InChI: 1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)
• InChI key: XHEQSRJCJTWWAH-UHFFFAOYSA-N

Description

Application

NU6140 has been used to study its effect on transcription factors NANOG, OCT4 (organic cation/carnitine transporter 4) and SOX2(SRY-box 2), involved in pluripotency of human embryonic stem (hES) cells and embryonal carcinoma-derived (hEC) cells.

Biochem/physiol Actions

NU6140 is a CDK2 inhibitor with 10-36-fold selectivity over other CDK family members. NU6140 induces apoptosis and cell cycle arrest in cancer cells in the G2-M phase, and potentiates the cytotoxic effects of paclitaxel.

NU6140 is a CDK2 inhibitor.

NU6140 is known to downregulate the expression of survivin protein, which possesses antiapoptotic activity and is generally overexpressed in cancer cells.[1]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable