SML0784

BMS-303141

Name: BMS-303141
Brand: SIGMA

≥98% (HPLC), ATP citrate lyase inhibitor, powder

Synonym(s):

3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1′-biphenyl]-3-yl)-benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₅Cl₂NO₄S

CAS Number:

943962-47-8

Molecular Weight:

424.30

NACRES:

NA.77

UNSPSC Code:

51111800

MDL number:

MFCD25976797

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Key Documents

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Product Name

BMS-303141, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(NC1=C(OC)C=CC(C2=CC=CC=C2)=C1)(C3=C(O)C(Cl)=CC(Cl)=C3)=O

InChI

1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3

InChI key

SIIPNDKXZOTLEA-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecules

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This Item	S5326	SML1152	SML2918
Sigma-Aldrich SML0784 BMS-303141	Sigma-Aldrich S5326 SB-271046A	Sigma-Aldrich SML1152 GSK137647A	Sigma-Aldrich SML2918 INT131
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 20 mg/mL, clear	solubility DMSO: >20 mg/mL	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 2 mg/mL, clear
color white to beige	color -	color white to beige	color white to beige

Application

BMS-303141 has been used for inhibition of ATP citrate lyase in breast cancer cell lines.

Biochem/physiol Actions

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL).

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC₅₀ of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.

hcodes

H413

pcodes

P273 - P501

Hazard Classifications

Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrence

Garcia MR, et al.

Cell Metabolism, 26, 842-855 (2017)

Massively multiplex chemical transcriptomics at single-cell resolution.

Sanjay R Srivatsan et al.

Science (New York, N.Y.), 367(6473), 45-51 (2019-12-07)

High-throughput chemical screens typically use coarse assays such as cell survival, limiting what can be learned about mechanisms of action, off-target effects, and heterogeneous responses. Here, we introduce "sci-Plex," which uses "nuclear hashing" to quantify global transcriptional responses to thousands

Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids.

Yi-Jia Li et al.

Cell reports, 39(9), 110870-110870 (2022-06-02)

Overcoming resistance to chemotherapies remains a major unmet need for cancers, such as triple-negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease.

Gabriella Assante et al.

Genome medicine, 14(1), 67-67 (2022-06-24)

The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well understood. Here we provide evidence that metabolically driven histone hyperacetylation in

A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate.

Massimo Bonora et al.

Cell stem cell, 31(3), 359-377 (2024-03-09)

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools

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Global Trade Item Number

SKU	GTIN
SML0784-5MG	04061833058510
SML0784-25MG	04061833058503

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