SML0004

(S)-(+)-Clopidogrel hydrogensulfate

≥98% (HPLC), Selective P2Y12 antagonist, powder

• Synonym(s): (S)-(+)-Clopidogrel bisulfate, (S)-(+)-Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrogensulfate, Clopidogrel Bisulphate
• Empirical Formula (Hill Notation): C₁₆H₁₆ClNO₂S · H₂SO₄
• CAS Number: 120202-66-6
• Molecular Weight: 419.90
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825081
• NACRES: NA.77
• MDL number: MFCD00876395
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: (S)-(+)-Clopidogrel hydrogensulfate, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +54 to +70°, c = 0.5 in methanol
• color: white to tan
• solubility: DMSO: ≥20 mg/mL (warmed)
• originator: Bristol-Myers Squibb, Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: OS(O)(=O)=O.COC(=O)[C@@H](N1CCc2sccc2C1)c3ccccc3Cl
• InChI: 1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)/t15-;/m0./s1
• InChI key: FDEODCTUSIWGLK-RSAXXLAASA-N
• Gene Information: human ... P2RY12(64805)

Description

Application

(S)-(+)-Clopidogrel hydrogensulfate was used as standard in HPLC-MS/MS to detect clopidogrel and its thiol derivative in human plasma.[1]

Biochem/physiol Actions

(S)-(+)-Clopidogrel hydrogen sulfate is an antithrombotic antiplatelet agent.

(S)-(+)-Clopidogrel hydrogen sulfate is an antithrombotic antiplatelet agent. It specifically and irreversibly inhibits the Purinoceptor P2Y12 subtype which inhibits ADP-induced platelet aggregation. (S)-(+)-Clopidogrel hydrogen sulfate is the active isomer.

Features and Benefits

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb and Sanofi Aventis. To browse the list of other pharma-developed compounds, Approved Drugs, and Drug Candidates, click here.

Safety Information

• pictograms: GHS05,GHS09
• signalword: Danger
• hcodes: H314,H411
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable