R2530

Ropinirole hydrochloride

≥98% (HPLC), D2 and D3 dopamine receptor agonist, powder

• Synonym(s): 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride, SKF 101468 hydrochloride
• Empirical Formula (Hill Notation): C₁₆H₂₄N₂O · HCl
• CAS Number: 91374-20-8
• Molecular Weight: 296.84
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824018
• NACRES: NA.77
• MDL number: MFCD01754173
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Ropinirole hydrochloride, powder, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: light yellow
• solubility: H₂O: >10 mg/mL
• originator: GlaxoSmithKline
• SMILES string: Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12
• InChI: 1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
• InChI key: XDXHAEQXIBQUEZ-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), DRD3(1814), DRD4(1815)

Description

Biochem/physiol Actions

Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.

An agonist at the D₂ and D₃ dopamine receptor subtypes, binding with higher affinity to D₃ than to D₂ or D₄. It has negligible effect on D₁-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT₁, 5-HT₂, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.

Selective D₂ dopamine receptor agonist, antiparkinsonian

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H400
• pcodes: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves