Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
R0875
Reserpine
Monoamine transport inhibitor
Synonym(s):
(3β, 16β, 17α, 18β, 20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
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About This Item
Empirical Formula (Hill Notation):
C33H40N2O9
CAS Number:
Molecular Weight:
608.68
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-047-9
MDL number:
Beilstein/REAXYS Number:
102014
Pricing and availability is not currently available.
Product Name
Reserpine,
Quality Segment
mp
~265 °C (dec.)
SMILES string
CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
InChI
1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
InChI key
QEVHRUUCFGRFIF-MDEJGZGSSA-N
Gene Information
Application
Reserpine has been used:
- to study its effect on minimal inhibitory concentration of trovafloxacin and ciprofloxacin
- inject rats, to study its effect on behavioural parameters such as locomotion and fear/anxiety
- as a lock spray reference compound in lipid profiling
Biochem/physiol Actions
Reserpine is an alkaloid present in Rauwolfia species. It is useful in treating systemic hypertension, schizophrenia, psychiatric disorders and Raynaud′s syndrome. Reserpine is known to inhibit adrenaline induced-cutaneous blood vessel constriction. It diminishes the effect of hyperthyroidism on cardiovascular and nervous system.
Inhibits vesicular uptake of catecholamines and serotonin.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| Gene Information human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC18A2(6571) | Gene Information human ... SLC18A2(6571) | Gene Information human ... SLC18A2(6571) | Gene Information human ... SLC18A2(6571) |
| mp ~265 °C (dec.) | mp ~265 °C (dec.) | mp ~265 °C (dec.) | mp ~265 °C (dec.) |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3
target_organs
Central nervous system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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What is the Department of Transportation shipping information for this product?
1 answer-
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Is Product R0875, Reserpine, synthetic?
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The initial product is derived from Rauwolfia species; the final product is chemically synthesized.
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Can solutions of Product R0875, Reserpine, be autoclaved?
1 answer-
You can filter sterilize the solution. Autoclaving is not recommended as it discolors the solution.
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What is the purity of Product R0875, Reserpine?
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The purity of each lot is given on the Certificate of Analysis; it is typically 98% as determined by Thin Layer Chromatography (TLC).
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What is the shelf life/expiration date of Product R0875, Reserpine?
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This product does not have an assigned shelf life or expiration date. The QC testing date is given on the certificate of analysis for each lot. The standard Sigma-Aldrich guarantee of one year from date of receipt applies.
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Is Product R0875, Reserpine, soluble in DMSO?
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Reserpine can be dissolved in DMSO at 50 mg/mL, according to Stevenson, P.A., et al., J. Neurobiol., 43(2), 107-120 (2000).
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What information do you have on the solubility of Product R0875, Reserpine?
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This product is soluble in chloroform at a concentration of 50 mg/mL. It is freely soluble in chloroform (approx. 1 g in 6 mL), methylene chloride, glacial acetic acid, benzene, ethyl acetate. It is slightly soluble in acetone, methanol, alcohol (1 g/1800 mL), ether, and in aqueous solutions of acetic and citric acids. It is very sparingly soluble in water.
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Where do you store Product R0875, Reserpine?
1 answer-
Product No. R0875 may be stored at ambient temperature, in a cool dry place.
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