N0267

(±)-Nicotine

≥99% (TLC), nicotinic acetylcholine receptor agonist, liquid

• Empirical Formula (Hill Notation): C₁₀H₁₄N₂
• CAS Number: 22083-74-5
• Molecular Weight: 162.23
• UNSPSC Code: 12352210
• eCl@ss: 39151701
• PubChem Substance ID: 24897418
• NACRES: NA.77
• Beilstein/REAXYS Number: 82108
• MDL number: MFCD00065370
• Assay: ≥99% (TLC)
• Form: liquid
• Quality level: 200

Properties

• Product Name: (±)-Nicotine, ≥99% (TLC), liquid
• Quality Level: 200
• assay: ≥99% (TLC)
• form: liquid
• optical activity: [α]25/D 0°(lit.)
• color: yellow
• solubility: ethanol: 50 mg/mL
• density: 1.02 g/mL at 25 °C (lit.)
• SMILES string: CN1CCCC1c2cccnc2
• InChI: 1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
• InChI key: SNICXCGAKADSCV-UHFFFAOYSA-N
• Gene Information: human ... CHRNA2(1135), CHRNA3(1136), CHRNA4(1137) ; rat ... Chrna3(25101), Chrna4(25590), Chrna7(25302)

Description

Application

(±)-Nicotine has been used:

• as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
• as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
• as a test compound to study its effects on fibril formation[1]

Biochem/physiol Actions

Prototype nicotinic acetylcholine receptor agonist.

(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.

Packaging

The material is liquid, transparent, and viscous, packaged in amber vail, and the volume inserted into each bottle is very small, It may form a thin FILM on the sides. While it may be difficult to see the material inside by the eyes, the container is not empty.

Safety Information

• pictograms: GHS06,GHS05,GHS09
• signalword: Danger
• hcodes: H300 + H310 + H330,H315,H318,H411
• pcodes: P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: 213.8 °F - closed cup
• flash_point_c: 101 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter