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N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin

Name: N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin
Brand: SIGMA

elastase substrate

Synonym(s):

MeOSuc-AAPV-AMC

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₄₁N₅O₉

CAS Number:

72252-90-5

Molecular Weight:

627.69

NACRES:

NA.32

PubChem Substance ID:

24897367

UNSPSC Code:

12352204

MDL number:

MFCD00077135

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Properties

Quality Segment

200

assay

≥98% (HPLC)

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

COC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C31H41N5O9/c1-16(2)27(30(42)34-20-9-10-21-17(3)14-26(39)45-23(21)15-20)35-29(41)22-8-7-13-36(22)31(43)19(5)33-28(40)18(4)32-24(37)11-12-25(38)44-6/h9-10,14-16,18-19,22,27H,7-8,11-13H2,1-6H3,(H,32,37)(H,33,40)(H,34,42)(H,35,41)

InChI key

CMEUDEVBFFPSEI-UHFFFAOYSA-N

Description

General description

Fluorogenic substrate for the assay of human leukocyte and porcine pancreatic elastase.

Application

N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin has been used as a substrate in elastase assay[1] using bone marrow lysates[2] and pancreatic lysates.[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item	S9761	T0273	A6220
Sigma-Aldrich M9771 N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin	Sigma-Aldrich S9761 N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin	Sigma-Aldrich T0273 N-p-Tosyl-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrochloride	Sigma-Aldrich A6220 N-Acetyl-Ile-Glu-Pro-Asp-7-amido-4-methylcoumarin
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (TLC)	assay ≥97% (HPLC)
solubility chloroform: 50 mg/mL, clear, colorless	solubility methanol: 50 mg/mL, clear, colorless	solubility acetic acid: 10 mg/mL, clear, colorless	solubility DMSO/DMF: 1 mg/mL
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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