Stock solutions for item I6138, Idazoxan hydrochloride, are stable for up to 3 months at -20°C.
M8046
Mifepristone
synthetic (organic), ≥98%, Progesterone receptor antagonist, powder
Synonym(s):
11β-(4-Dimethylamino)phenyl-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-38486, RU-486
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About This Item
Empirical Formula (Hill Notation):
C29H35NO2
CAS Number:
Molecular Weight:
429.59
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98%
Form:
powder
Pricing and availability is not currently available.
Product Name
Mifepristone, ≥98%
biological source
synthetic (organic)
sterility
non-sterile
assay
≥98%
form
powder
technique(s)
inhibition assay: suitable
solubility
ethanol: 50 mg/mL, clear, greenish-yellow
originator
Danco Laboratories
shipped in
ambient
storage temp.
2-8°C
SMILES string
[H][C@@]12CCC3=CC(=O)CCC3=C1[C@H](C[C@@]4(C)[C@@]2([H])CC[C@@]4(O)C#CC)c5ccc(cc5)N(C)C
InChI
1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
InChI key
VKHAHZOOUSRJNA-GCNJZUOMSA-N
Gene Information
human ... AR(367), ESR1(2099), ESR2(2100), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), NR3C1(2908), NR3C2(4306), PGR(5241)
mouse ... Nr3c1(14815)
rat ... Nr3c1(24413), Tat(24813)
General description
Mifepristone, a synthetic steroid, can be utilized for the management of Cushing′s syndrome and uterine leiomyomas. At low doses, it selectively antagonizes progesterone by binding to the intracellular progesterone receptor. At higher doses, mifepristone blocks cortisol at the glucocorticoid receptor, affecting the hypothalamic-pituitary-adrenal axis and leading to increased circulating cortisol, thereby controlling hyperglycemia in some patients. Additionally, mifepristone has a higher affinity for the glucocorticoid II receptor than for the glucocorticoid I receptor. In cases of pregnancy termination, mifepristone disrupts progesterone.
Application
Mifepristone has been used:
- to induce damage against the proliferative and secretory phase of endometrial stromal cells
- to establish a preterm birth (PTB) mice model in order to study the difference in cervical ripening mechanism between term and PTBs
- to activate geneswitch gal4 in flies
- to study the effects of sex steroids on prostaglandin secretion
Biochem/physiol Actions
Therefore, mifepristone is considered to be a potent abortifacient. It is also known to inhibit human chorionic gonadotropin. Mifepristone results in decidual necrosis.
Mifepristone (RU-486) has activity as both a progesterone receptor antagonist and a glucocorticoid receptor antagonist.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Danco Laboratories. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| technique(s) inhibition assay: suitable | technique(s) - | technique(s) - | technique(s) - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility ethanol: 50 mg/mL, clear, greenish-yellow | solubility DMSO: ≥10 mg/mL | solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: ≥15 |
| originator Danco Laboratories | originator - | originator - | originator Bayer |
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Product Information Sheet
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M8046-100MG | 04061834062660 |
| M8046-1G | 04061834062677 |
| M8046-500MG | 04061834062684 |
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How should stock solutions for item I6138, Idazoxan hydrochloride, be stored?
1 answer-
Helpful?
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What are the recommended storage conditions for stock solutions of Mifepristone (item M8046)?
1 answer-
The stock solutions of Mifepristone (item M8046) can be stored at -20°C and remain stable for up to 3 months.
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What is the recommended method for storing stock solutions of item P0884, (±)-Propranolol hydrochloride?
1 answer-
For P0884, stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. Typically, the stock solution can be kept for several months.
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What are the recommended storage conditions for stock solutions of item A8727, Antalarmin hydrochloride?
1 answer-
Store stock solutions of item A8727, Antalarmin hydrochloride below -20°C and ensure a tight seal before storage.
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How many pills is in the container of mifepristone ( 100mg)
1 answer-
This item is supplied in a powder form, not in a pill form. Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Can solutions of Mifepristone, Product M8046, be stored?
1 answer-
Stock solutions of 1 mM mifepristone in ethanol can be stored at -20 °C. The top of the container should be sealed with Parafilm to prevent solvent evaporation. Solutions in ethanol, properly stored and handled, are probably good for several months (based on the structure of the compound), but we have no specific information on this.
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Where can I find information on usage of Mifepristone, Product M8046?
1 answer-
The Sigma-Aldrich website listing has several cited articles with hyperlinks to the abstracts. These references can be found under the reference tab on the M8046 product webpage.
Helpful?
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What is Mifepristone, Product M8046, soluble in?
1 answer-
Mifepristone is soluble in ethanol at 50 mg/mL; heat may be required to dissolve the compound at this concentration. It is also soluble in DMSO at 20 mg/mL.
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