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Loxapine succinate salt

Name: Loxapine succinate salt
Brand: SIGMA

solid

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₈ClN₃O · C₄H₆O₄

CAS Number:

27833-64-3

Molecular Weight:

445.90

NACRES:

NA.77

PubChem Substance ID:

24277719

UNSPSC Code:

12352200

EC Number:

248-682-0

MDL number:

MFCD00069298

Form:

solid

Quality level:

100

Pricing and availability is not currently available.

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Properties

form

solid

Quality Level

100

color

white

solubility

H₂O: soluble

originator

Watson

SMILES string

CN(CC1)CCN1C2=NC3=C(C=CC=C3)OC4=C2C=C(Cl)C=C4.OC(CCC(O)=O)=O

InChI

1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)

InChI key

YQZBAXDVDZTKEQ-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR7(3363)

Description

Biochem/physiol Actions

D₂/D₄ dopamine receptor antagonist; 5-HT_2A/2B, 5-H₇ serotonin receptor antagonist; dibenzoxazepine antipsychotic agent.

Features and Benefits

This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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1 of 1

This Item	P1372	S1442	R134
Sigma-Aldrich L106 Loxapine succinate salt	Sigma-Aldrich P1372 Paroxetine maleate salt	Sigma-Aldrich S1442 Sordarin sodium salt	Sigma-Aldrich R134 Rilmenidine hemifumarate salt
form solid	form solid	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
solubility H₂O: soluble	solubility DMSO: ~12 mg/mL, H₂O: insoluble	solubility H₂O: soluble ≤10 mg/mL	solubility DMSO: >10 mg/mL, H₂O: insoluble
color white	color white to off-white	color -	color white
originator Watson	originator GlaxoSmithKline	originator -	originator Servier
Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR7(3363)	Gene Information human ... SLC6A4(6532)	Gene Information -	Gene Information human ... NISCH(11188)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat.

H O Kalkman et al.

British journal of pharmacology, 124(7), 1550-1556 (1998-09-02)

1. The mechanism underlying the anticataleptic properties of the atypical neuroleptic agent, clozapine, has been investigated in the rat. 2.The close structural analogues of clozapine, loxapine (0.1 mg kg(-1) s.c.) and iso-clozapine (1 and 3 mg kg(-1) s.c.) induced catalepsy

Inhaled loxapine: a new treatment for agitation in schizophrenia or bipolar disorder.

R T Owen

Drugs of today (Barcelona, Spain : 1998), 49(3), 195-201 (2013-03-26)

The treatment of acute agitation in psychiatric patients has traditionally involved the use of oral or intramuscular benzodiazepines, antipsychotics or their combination. However, oral medication may have too slow an onset and while the intramuscular route is faster, it carries

Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors.

E Glusa et al.

British journal of pharmacology, 130(3), 692-698 (2000-05-24)

The endothelial 5-HT receptor mediating relaxation of pig pulmonary artery has been characterized using the selective 5-HT(2B) receptor agonist BW 723C86 and a variety of structurally diverse 5-HT receptor antagonists. If arterial rings with intact endothelium were precontracted with prostaglandin

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Global Trade Item Number

SKU	GTIN
L106-100MG	04061832091679
L106-500MG	04061833949214

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Loxapine succinate salt

solid

Select a Size

About This Item

form

Quality Level

color

solubility

originator

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

Features and Benefits

Compare Similar Items

This Item

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Storage Class

wgk

flash_point_f

flash_point_c

ppe

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