H6012

4-Hydroxyestrone

≥90% (HPLC)

• Synonym(s): 1,3,5(10)-Estratriene-3,4-diol-17-one
• Empirical Formula (Hill Notation): C₁₈H₂₂O₃
• CAS Number: 3131-23-5
• Molecular Weight: 286.37
• NACRES: NA.77
• PubChem Substance ID: 24895725
• UNSPSC Code: 51111800
• MDL number: MFCD00079358
• Assay: ≥90% (HPLC)
• Form: powder

Properties

• sterility: non-sterile
• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: powder
• solubility: methanol: 10 mg/mL, clear, colorless to faintly brownish-yellow
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4c(O)c(O)ccc24
• InChI: 1S/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11-,12-,14+,18+/m1/s1
• InChI key: XQZVQQZZOVBNLU-QDTBLXIISA-N

Description

Biochem/physiol Actions

4-Hydroxyestrone is an endogenous estrogen metabolite, which exhibits a strong neuroprotective effect against oxidative damage. It also provides effective protection against kanic acid-induced hippocampal oxidative damage in rats when compared to 17β-estradiol. 4-Hydroxyestrone regulates the angiogenic process during corpus luteum formation. It might be involved in an increased risk of cancer. 4-Hydroxyestrone is found in the early and mid-luteal phases.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: 199.9 °F - closed cup
• flash_point_c: 93.3 °C - closed cup
• ppe: Eyeshields, Gloves, type N95 (US)