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H5784

(2-Hydroxypropyl)-β-cyclodextrin solution

Synonym(s):

Hydroxypropyl-β-cyclodextrin

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About This Item

Linear Formula:
(C6H9O5)7 · (C3H7O)4.5
NACRES:
NA.77
PubChem Substance ID:
24895710
UNSPSC Code:
12352201
MDL number:
MFCD00069372
Form:
solution (clear, colorless)
Pricing and availability is not currently available.
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biological source

synthetic (organic)

Quality Level

200

form

solution (clear, colorless)

mol wt

~1396 Da

concentration

45 % (w/v) in H2O

storage temp.

2-8°C

SMILES string

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C105H196O56/c1-50(106)22-127-43-71-78-85(134-29-57(8)113)92(141-36-64(15)120)99(148-71)156-79-72(44-128-23-51(2)107)150-101(94(143-38-66(17)122)86(79)135-30-58(9)114)158-81-74(46-130-25-53(4)109)152-103(96(145-40-68(19)124)88(81)137-32-60(11)116)160-83-76(48-132-27-55(6)111)154-105(98(147-42-70(21)126)90(83)139-34-62(13)118)161-84-77(49-133-28-56(7)112)153-104(97(146-41-69(20)125)91(84)140-35-63(14)119)159-82-75(47-131-26-54(5)110)151-102(95(144-39-67(18)123)89(82)138-33-61(12)117)157-80-73(45-129-24-52(3)108)149-100(155-78)93(142-37-65(16)121)87(80)136-31-59(10)115/h50-126H,22-49H2,1-21H3

InChI key

DCQLZTSRKLWEAB-UHFFFAOYSA-N

General description

2-hydroxypropyl-β-cyclodextrin is obtained by chemical modification of cyclic oligosaccharide, β-cyclodextrins. It is used as a potential adjuvant for vaccines. 2-hydroxypropyl-β-cyclodextrin in an aqueous buffer increases the solubility of drugs. It is non-toxic in mice and rabbits. The formation of drug/cyclodextrin complexes is a rapidly reversible reaction and complexes exist both in solution and crystalline states. Solutions of many such complexes may be lyophilized to produce freely soluble powders which may be compressed into tablets.

Application

(2-Hydroxypropyl)-β-cyclodextrin solution has been used:
  • to prepare a fresh solution of Cdc42 activity-specific inhibitor (CASIN) drug for analysis of the epigenetic aging signature in C57BL/6 mice
  • to prepare the solution of remodelin and remodelin Fluor for assessment of remodelin toxicity in vivo in mice
  • as a constituent of sodium citrate solution for reconstitution of carfilzomib (PR-171)

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This Item
332607389145C0926
(2-Hydroxypropyl)-β-cyclodextrin solution

Sigma-Aldrich

H5784

(2-Hydroxypropyl)-β-cyclodextrin solution

(2-Hydroxypropyl)-β-cyclodextrin average Mw ~1,460

Sigma-Aldrich

332607

(2-Hydroxypropyl)-β-cyclodextrin

(2-Hydroxypropyl)-β-cyclodextrin average Mw ~1,540

Sigma-Aldrich

389145

(2-Hydroxypropyl)-β-cyclodextrin

(2-Hydroxypropyl)-β-cyclodextrin powder, BioReagent, suitable for cell culture

Sigma-Aldrich

C0926

(2-Hydroxypropyl)-β-cyclodextrin

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

300

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

room temp

form

solution (clear, colorless)

form

powder

form

powder

form

powder

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

corn starch

concentration

45 % (w/v) in H2O

concentration

-

concentration

-

concentration

-

mol wt

~1396 Da

mol wt

average Mw ~1,460

mol wt

average Mw ~1,540

mol wt

1396 Da

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000384021
0000372427
0000384021
0000372427
SLCN4502

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Min K Lee et al.
Pain, 139(2), 367-375 (2008-06-21)
This study provides the first demonstration that central cannabinoids modulate the antinociceptive actions of metabotropic glutamate receptors (mGluRs) on formalin-induced temporomandibular joint (TMJ) nociception. Noxious scratching behavior induced by formalin injection in the TMJ was used as a model of
Sun Kyung Kim et al.
Frontiers in immunology, 7, 435-435 (2016-11-05)
2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a chemically modified cyclic oligosaccharide produced from starch that is commonly used as an excipient. Although HP-β-CD has been suggested as a potential adjuvant for vaccines, its immunological properties and mechanism of action have yet to be
Maria Carolina Florian et al.
Aging cell, 19(9), e13208-e13208 (2020-08-06)
Cdc42 is a small RhoGTPase regulating multiple functions in eukaryotic cells. The activity of Cdc42 is significantly elevated in several tissues of aged mice, while the Cdc42 gain-of-activity mouse model presents with a premature aging-like phenotype and with decreased lifespan.
View All Related Papers

Global Trade Item Number

SKUGTIN
H5784-10ML04061833799772

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