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p-Fluorohexahydro-sila-difenidol hydrochloride

Name: <I>p</I>-Fluorohexahydro-sila-difenidol hydrochloride
Brand: SIGMA

powder, ≥98% (HPLC)

Synonym(s):

Cyclohexyl-(4-fluorophenyl)-(3-N-piperidinopropyl)silanol hydrochloride, P-F-HHSiD hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₃₂FNOSi · HCl

CAS Number:

116679-83-5

Molecular Weight:

386.02

NACRES:

NA.77

PubChem Substance ID:

24277841

UNSPSC Code:

12352200

MDL number:

MFCD00078582

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: slightly soluble 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL, ethanol: soluble

SMILES string

Cl[H].O[Si](CCCN1CCCCC1)(C2CCCCC2)c3ccc(F)cc3

InChI

1S/C20H32FNOSi.ClH/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22;/h10-13,19,23H,1-9,14-17H2;1H

InChI key

JMTYYLMGSBSPPK-UHFFFAOYSA-N

Gene Information

human ... CHRM3(1131)

Description

Application

p-Fluorohexahydro-sila-difenidol hydrochloride (pFHHSid) has been used:

as the M3/muscarinic acetylcholine receptor antagonist to study its involvement in carbachol induced Egr-1 biosynthesis using human neuroblastoma cells[1]
as M3 receptor antagonist to test its involvement on N,N-diethyl-m-toluamide (DEET)-induced angiogenesis in human umbilical venous endothelial cells (HUVEC)[2]
in a study to examine the role of aclidinium on human fibroblast to myofibroblast[3]

Biochem/physiol Actions

High affinity M₃ muscarinic acetylcholine receptor antagonist.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	SML2324	SML0897	H1512
Sigma-Aldrich H127 p-Fluorohexahydro-sila-difenidol hydrochloride	Sigma-Aldrich SML2324 NLX-112 hydrochloride	Sigma-Aldrich SML0897 ALX 5407 hydrochloride	Sigma-Aldrich H1512 Haloperidol
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay -
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 200
solubility H₂O: slightly soluble 1.5 mg/mL, ethanol: soluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 5 mg/mL, clear (warmed)	solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL, 0.1 M HCl: 3 mg/mL, DMSO: soluble, H₂O: insoluble, ethanol: soluble
color white to beige	color white to beige	color white to beige	color white
Gene Information human ... CHRM3(1131)	Gene Information -	Gene Information -	Gene Information human ... ABCB1(5243), ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), EBP(10682), HRH1(3269), HTR2A(3356), HTR2C(3358), HTR7(3363), KCNH1(3756), KCNH2(3757), PRNP(5621) rat ... Adra1a(29412), Adra2a(25083), Chrm1(25229), Chrm2(81645), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2c(25187), Oprs1(29336), Slc6a3(24898), Slc6a4(25553)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Global Trade Item Number

SKU	GTIN
H127-50MG	04061832082332
H127-10MG	04061833664841

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