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H125

(2-Hydroxypropyl)-γ-cyclodextrin

solid

Synonym(s):

HGC

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About This Item

CAS Number:
128446-34-4
UNSPSC Code:
12352201
NACRES:
NA.77
Pricing and availability is not currently available.
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form

solid

Quality Level

100

concentration

1.000 mg/mL±0.005

technique(s)

cell culture | mammalian: suitable

color

white

solubility

H2O: 450 mg/mL

shipped in

ambient

storage temp.

room temp

SMILES string

O1[C@@H]2O[C@H]([C@H](O[C@@H]3O[C@H]([C@H](O[C@@H]4O[C@H]([C@H](O[C@@H]5O[C@H]([C@H](O[C@@H]6O[C@H]([C@H](O[C@@H]7O[C@H]([C@H](O[C@@H]8O[C@H]([C@H]1[C@H]([C@@H]8O)O)COCC(O)C)[C@H]([C@@H]7O)O)CO)[C@H]([C@@H]6O)O)COCC(O)C)[C@H]([C@@H]5O)O)CO)[C@H]([C@@H]4O)

InChI

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

Application

(2-Hydroxypropyl)-γ-cyclodextrin has been used to study its inhibitory effect on complement products and the inflammation induced by cholesterol crystals (CCs) from plasma samples.[1]

Biochem/physiol Actions

(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble alkylated cyclodextrin derivative.[2] It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations. It solubilizes macromolecules, such as cholesterol.[3] It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis.[3] In the Niemann pick disease model, HPγCD reduces cholesterol accumulation.[3]

Other Notes

Non-toxic solubilizer. γ-Cyclodextrin (8-glucose units) has a slightly larger cavity and can accommodate larger substrates than β-cyclodextrin.

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This Item
C4805C4930H0396
(2-Hydroxypropyl)-γ-cyclodextrin solid

Sigma-Aldrich

H125

(2-Hydroxypropyl)-γ-cyclodextrin

β-Cyclodextrin powder, BioReagent, suitable for cell culture, ≥97%

Sigma-Aldrich

C4805

β-Cyclodextrin

γ-Cyclodextrin powder, BioReagent, suitable for cell culture, ≥98%

Sigma-Aldrich

C4930

γ-Cyclodextrin

Hydrocortisone-Water Soluble BioReagent, suitable for cell culture

Sigma-Aldrich

H0396

Hydrocortisone-Water Soluble

form

solid

form

powder

form

powder

form

crystalline

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

solubility

H2O: 450 mg/mL

solubility

1 M NaOH: 50 mg/mL

solubility

1 M NaOH: 25 mg/mL, clear to slightly hazy

solubility

H2O: 400 mg/mL

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP4781
BCCN9339
BCCN4361
BCCL3182
BCCK3457

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Osmir F L Macedo et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 86, 101-106 (2011-11-08)
Here we report the preparation of a trimethoprim/2-hydroxypropyl-γ-cyclodextrin inclusion complex along with a physicochemical study, structural characterization, and molecular modeling of the complex. As main results, we observed from phase-solubility studies at two temperatures (20 °C and 35 °C) that
Role of cyclodextrins in improving oral drug delivery
Loftsson T, et al.
The American Journal of Drug and Alcohol Abuse, 261-275 (2004)
Ashutosh Singhal et al.
Scientific reports, 10(1), 8663-8663 (2020-05-28)
Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused by mutations in NPC1 and NPC2 genes that result in an accumulation of cholesterol in lysosomes. The majority of children with NPC die in adolescence. Currently, no FDA-approved therapies
View All Related Papers

Global Trade Item Number

SKUGTIN
H125-5G-I04061833664742
H125-1G-A04061826675045
H125-100G-I04061833664728

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