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D9760

L-(−)-Dithiothreitol

≥95% (titration)

Synonym(s):

(−)-Cleland’s Reagent, (2R,3R)-1,4-Dimercapto-2,3-butanediol, L-DTT, Cleland reagent chiral

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About This Item

Empirical Formula (Hill Notation):
C4H10O2S2
CAS Number:
16096-97-2
Molecular Weight:
154.25
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24894326
EC Number:
240-263-0
Beilstein/REAXYS Number:
2036371
MDL number:
MFCD00064305
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assay

≥95% (titration)

form

powder

color

white

mp

49 - 51 °C ((120 - 124 °F))

solubility

H2O: 50 mg/mL, clear to hazy, colorless

storage temp.

−20°C

SMILES string

O[C@@H](CS)[C@@H](O)CS

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1

InChI key

VHJLVAABSRFDPM-IMJSIDKUSA-N

Application

L-DTT [(2R,3R)-1,4-dimercapto-2,3-butanediol; L-dithiothreitol], a chiral bidentate dithiol with two stereogenic centers, may be used in chiroptical response research. L-DDT is proposed as a stereoselective reducing agent for disulfide bridges in complex molecules.[1][2]

Other Notes

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This Item
43819D9163D5545
L-(−)-Dithiothreitol ≥95% (titration)

Sigma-Aldrich

D9760

L-(−)-Dithiothreitol

DL-Dithiothreitol ≥99.0% (RT)

Sigma-Aldrich

43819

DL-Dithiothreitol

DL-Dithiothreitol suitable for electrophoresis, ≥99%

Sigma-Aldrich

D9163

DL-Dithiothreitol

DL-Dithiothreitol BioXtra, ≥99.0% (titration)

Sigma-Aldrich

D5545

DL-Dithiothreitol

assay

≥95% (titration)

assay

≥99.0% (RT)

assay

≥99%

assay

≥99.0% (titration)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

solubility

H2O: 50 mg/mL, clear to hazy, colorless

solubility

H2O: 50 mg/mL, clear, colorless, H2O: freely soluble, acetone: freely soluble, chloroform: freely soluble, diethyl ether: freely soluble, ethanol: freely soluble, ethyl acetate: freely soluble

solubility

H2O: 50 mg/mL, clear, colorless to very faintly yellow

solubility

H2O: 0.1 M, clear, colorless

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mp

49 - 51 °C ((120 - 124 °F))

mp

40-43 °C, 41-44 °C (lit.)

mp

40-44 °C, 41-44 °C (lit.)

mp

41-44 °C (lit.)

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCS7914
MKCT2496
WXBD9744V
MKCQ3488
MKCP4074

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Valérie Robin et al.
Molecular therapy. Nucleic acids, 7, 81-89 (2017-06-19)
Spinal muscular atrophy (SMA) is a recessive disease caused by mutations in the SMN1 gene, which encodes the protein survival motor neuron (SMN), whose absence dramatically affects the survival of motor neurons. In humans, the severity of the disease is
Hiroshi Yao et al.
Langmuir : the ACS journal of surfaces and colloids, 29(21), 6444-6451 (2013-05-03)
We here present a study of cross-linking chemistry of optically inactive monothiol-protected gold clusters by chiral bidentate dithiol with two stereogenic centers, (2R,3R)-1,4-dimercapto-2,3-butanediol (L-dithiothreitol; L-DTT), and explore the impacts of the cross-linking on their chiroptical responses. The pristine protective ligand
Stefan Knoppe et al.
Chimia, 67(4), 236-239 (2013-08-24)
Chiral thiolate-protected gold clusters of atomic precision have gained increasing interest in recent years due to their potential use in catalysis, sensing or bioapplications. While the protection of gold clusters with chiral ligands is a rather trivial task, it was
View All Related Papers

Global Trade Item Number

SKUGTIN
D9760-1G04061833591079
D9760-500MG04061833591086

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