C5857

CA-074 methyl ester

≥99% (TLC)

• Synonym(s): (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester
• Empirical Formula (Hill Notation): C₁₉H₃₁N₃O₆
• CAS Number: 147859-80-1
• Molecular Weight: 397.47
• NACRES: NA.77
• PubChem Substance ID: 329775104
• UNSPSC Code: 12352108
• MDL number: MFCD03452890
• Assay: ≥99% (TLC)
• Form: solid

Properties

• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥99% (TLC)
• form: solid
• storage temp.: −20°C
• SMILES string: CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC
• InChI: 1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11?,12-,13-,14-,15-/m0/s1
• InChI key: XGWSRLSPWIEMLQ-RQLZCWDZSA-N

Description

Application

CA-074 methyl ester has been used as cathepsin B inhibitor in cardiomyocytes, HeLa cells and human pancreatic cancer PANC-1 cells.

Biochem/physiol Actions

CA-074 methyl ester is a cell-permeable analog of CA-074. It is an inhibitor of cathepsin B especially the intracellular type. and undergoes intracellular transition into active CA-074 by the action of esterases. CA-074 methyl ester also inhibits cathepsin L.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)