C3678
Anti-Pan Cadherin antibody produced in rabbit
whole antiserum
Synonym(s):
Anti-ACOGS, Anti-ARVD14, Anti-CD325, Anti-CDHN, Anti-CDw325, Anti-NCAD
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC (p), WB
Citations:
55
Pricing and availability is not currently available.
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
mol wt
antigen 135 kDa
contains
15 mM sodium azide
species reactivity
rabbit, cat, chicken, human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using protease-digested animal heart sections, indirect immunofluorescence: 1:100 using cultured MDBK cells, western blot: 1:200
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
chicken ... CDH2(414745)
General description
Cadherins are glycoprotein receptors that regulate Ca2+-dependant adhesion in cells. Cadherins are associated with adherens junctions and are mainly involved in morphogenesis of cells and tissues. P-cadherin is expressed in epithelial cells and its over-expression has been associated with breast cancer metastasis and invasion . Anti-Pan Cadherin antibody is specific for cadherins in a wide range of organisms including chickens, rabbits and rats.
Immunogen
Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue (24 amino acids) coupled with glutaraldehyde to keyhole limpet hemocyanin (KLH).
Application
Anti-Pan Cadherin antibody is suitable for use in confocal immunofluorescence using rat ventricular myocytes and western blot (1:200). The antibody may also be used for indirect immunofluorescence (1:100 using cultured MDBK cells) and immunohistochemistry (in formalin-fixed, paraffin-embedded sections or at 1:1,000 dilutions using protease-digested animal heart sections). Additionally, the product can be used in indirect immunoblot (135 kDa band in chicken or rabbit heart extracts), immunoperoxidase and immunoelectron-microscopy assays.
May be used for the detection of members of the cadherin family or genetically engineered proteins containing the C-terminal cadherin tail, and for demonstration of adherens type cell-cell junctions regardless of their cadherin type.
Biochem/physiol Actions
The epitope recognized by the antibody is shared by a wide variety of organisms.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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This Item | |||
|---|---|---|---|
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| biological source rabbit | biological source mouse | biological source rabbit | biological source mouse |
| antibody form whole antiserum | antibody form ascites fluid | antibody form affinity isolated antibody | antibody form purified immunoglobulin |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| mol wt antigen 135 kDa | mol wt antigen 135 kDa | mol wt antigen ~130 kDa | mol wt antigen 135 kDa |
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Storage Class
12 - Non Combustible Liquids
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Sang-Jin Lee et al.
Cell death & disease, 7(10), e2431-e2431 (2016-10-21)
Skeletal myogenesis is coordinated by multiple signaling pathways that control cell adhesion/migration, survival and differentiation accompanied by muscle-specific gene expression. A cell surface protein Cdo is involved in cell contact-mediated promyogenic signals through activation of p38MAPK and AKT. Protein kinase
Laura Pelz et al.
The Journal of biological chemistry, 292(52), 21490-21503 (2017-11-11)
The Ig-like cell adhesion molecule (IgCAM) BT-IgSF (brain- and testis-specific Ig superfamily protein) plays a major role in male fertility in mice. However, the molecular mechanism by which BT-IgSF supports fertility is unclear. Here, we found that it is localized
Kiyomi Yamada et al.
Circulation research, 97(4), 346-353 (2005-07-23)
To define mechanisms regulating expression of cell-cell junction proteins, we have developed an in vitro system in which neonatal rat ventricular myocytes were subjected to pulsatile stretch. Previously, we showed that expression of the gap junction protein, connexin (Cx) 43
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C3678-.2ML | 04061837873164 |