Key Documents

Anti-Calcium Channel (α_1D Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit

Name: Anti-Calcium Channel (α<SUB>1D</SUB> Subunit) (L-type of Voltage-gated Ca<SUP>2+</SUP> Channel) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-CACH3, Anti-CACN4, Anti-CACNL1A2, Anti-CCHL1A2, Anti-Cav1.3, Anti-PASNA, Anti-SANDD

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02095953

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ICC, IP, WB CL

Citations:

Pricing and availability is not currently available.

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat

technique(s)

immunocytochemistry: 1:30-1:150, immunoprecipitation (IP): suitable, western blot (chemiluminescent): 1:100-1:200

UniProt accession no.

Q99246

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CACNA1D(776)
mouse ... Cacna1d(12289)
rat ... Cacna1d(29716)

Description

Immunogen

synthetic peptide corresponding to amino acids 859-875 of rat α_1D (Accession P27732). This epitope is highly conserved in human and hamster.

Application

Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for the following applications:

immunocytochemistry at a dilution of 1:30-1:150
immunoprecipitation
western blot (chemiluminescent) at a dilution of 1:100-1:200

Biochem/physiol Actions

Ca_v1.3 also known as the calcium channel, voltage-dependent, L type, α1D subunit (CACNA1D), is a human gene. It responds more sensitively to depolarization than those of Ca_v1.2 or Ca_v3.1. Ca_v1.3 is required for proper hearing as well as sinoatrial node and brain function. It undergoes extensive alternative splicing. Alternative splicing in the C terminus and drastically modifies gating properties of the channel. The L-type calcium channel Ca_v1.3 is important in human glucose-induced insulin secretion and common variants in CACNA1D may contribute to type 2 diabetes.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	C1868	C1478	SAB2107922
Sigma-Aldrich C1728 Anti-Calcium Channel (α_1D Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit	Sigma-Aldrich C1868 Anti-Calcium Channel Ca_V3.2 (α1H) antibody produced in rabbit	Sigma-Aldrich C1478 Anti-Calcium Channel (α_1B Subunit) (N-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit	Sigma-Aldrich SAB2107922 Anti-CACNA2D1 antibody produced in rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
species reactivity mouse, rat	species reactivity rat	species reactivity rat, mouse	species reactivity horse, rat, human, guinea pig, mouse, rabbit, bovine, dog
technique(s) immunocytochemistry: 1:30-1:150, western blot (chemiluminescent): 1:100-1:200, immunoprecipitation (IP): suitable	technique(s) western blot: 1:200 using lysate from the ND7/23 cell line	technique(s) immunocytochemistry: suitable using rat brain sections, immunoprecipitation (IP): suitable, western blot: 1:100-1:200 using rat brain membranes	technique(s) immunoblotting: suitable

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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C-terminal alternative splicing of CaV1.3 channels distinctively modulates their dihydropyridine sensitivity.

Hua Huang et al.

Molecular pharmacology, 84(4), 643-653 (2013-08-09)

The transcripts of L-type voltage-gated calcium channels (CaV) 1.3 undergo extensive alternative splicing. Alternative splicing, particularly in the C terminus, drastically modifies gating properties of the channel. However, little is known about whether alternative splicing could modulate the pharmacologic properties

C-terminal modulatory domain controls coupling of voltage-sensing to pore opening in Cav1.3 L-type Ca(2+) channels.

Andreas Lieb et al.

Biophysical journal, 106(7), 1467-1475 (2014-04-08)

Activity of voltage-gated Cav1.3 L-type Ca(2+) channels is required for proper hearing as well as sinoatrial node and brain function. This critically depends on their negative activation voltage range, which is further fine-tuned by alternative splicing. Shorter variants miss a

The human L-type calcium channel Cav1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes.

T M Reinbothe et al.

Diabetologia, 56(2), 340-349 (2012-12-12)

Voltage-gated calcium channels of the L-type have been shown to be essential for rodent pancreatic beta cell function, but data about their presence and regulation in humans are incomplete. We therefore sought to elucidate which L-type channel isoform is functionally

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Global Trade Item Number

SKU	GTIN
C1728-.2ML	04061838172082

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