Solutions prepared in DMSO at 50 mg/mL may be stored in working aliquots at -20°C for up to 1 year. Avoid repeated freeze/thaw cycles.
92131
Trimethoprim
≥99.0% (HPLC)
Synonym(s):
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, NSC 106568
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About This Item
Empirical Formula (Hill Notation):
C14H18N4O3
CAS Number:
Molecular Weight:
290.32
UNSPSC Code:
51285203
NACRES:
NA.85
PubChem Substance ID:
EC Number:
212-006-2
Beilstein/REAXYS Number:
625127
MDL number:
Pricing and availability is not currently available.
biological source
synthetic
Quality Segment
assay
≥99.0% (HPLC)
form
powder
color
white to light yellow
mp
≥199.0 °C
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI
1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChI key
IEDVJHCEMCRBQM-UHFFFAOYSA-N
Gene Information
human ... DHFRP1(573971), KCNH1(3756)
rat ... Dhfr(24312)
General description
Chemical structure: pyrimidine
Application
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis and mechanism of resistance studies in Haemophilus influenzae [1].
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Packaging
1g,5g,25g
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.
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This Item | |||
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria, mycobacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycoplasma | antibiotic activity spectrum - |
| mode of action enzyme | inhibits, DNA synthesis | interferes | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level - |
| form powder | form powder | form - | form powder |
| assay ≥99.0% (HPLC) | assay ≥98.5% | assay - | assay - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 92131-25G | 04061833418154 |
| 92131-5G | 04061833269169 |
| 92131-1G | 04061833269152 |
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Upon dilution in DMSO, what is the best storage condition for trimethoprim (fridge/freezer, how long is it stable for)?
1 answer-
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Is Trimethoprim soluble in DMSO or water?
1 answer-
The solubility of this product is not analyzed on a lot-to-lot basis. The compound is expected to be soluble in water at 0.4 mg/ml, ethanol at 2.6 mg/ml, methanol at 12.1 mg/ml, chloroform at 22.2 mg/ml, and DMSO at 50 mg/ml.
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Is Trimethoprim stable in solution?
1 answer-
Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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