79849
(±)-Mevalonic acid 5-phosphate lithium salt hydrate
95% (TLC)
Synonym(s):
(±)-MVAP-Li, rac-5-Phosphomevalonate lithium salt
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About This Item
Empirical Formula (Hill Notation):
C6H13O7P · xLi+ · yH2O
Molecular Weight:
228.14 (free acid basis)
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
Quality Level
assay
95% (TLC)
form
powder or crystals
relevant disease(s)
Alzheimer′s disease; autoimmune diseases
storage temp.
2-8°C
SMILES string
OC(CC(C)(O)CCOP(O)(O)=O)=O.[H]O[H].[Li+]
InChI
1S/C6H13O7P.3Li.H2O/c1-6(9,4-5(7)8)2-3-13-14(10,11)12;;;;/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12);;;;1H2/q;3*+1;/p-3
InChI key
VYTYNAKRCDFACM-UHFFFAOYSA-K
Biochem/physiol Actions
Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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John L Andreassi et al.
Biochemistry, 48(27), 6461-6468 (2009-06-03)
The galacto-, homoserine-, mevalonate-, phosphomevalonate-kinase (GHMP) superfamily encompases a wide-range of protein function. Three members of the family (mevalonate kinase, phosphomevalonate kinase, and diphosphomevalonate decarboxylase) comprise the mevalonate pathway found in S. pneumoniae and other organisms. We have determined the
Inhibition of hepatic cholesterol biosynthesis by 3,5-dihydroxy-3,4,4-trimethylvaleric acid and its site of action.
F H Hulcher
Archives of biochemistry and biophysics, 146(2), 422-427 (1971-10-01)
Li Gong et al.
Cell death & disease, 10(4), 327-327 (2019-04-13)
The mevalonate pathway is known for the synthesis of cholesterol, but recent studies have reported that it also controls Hippo signaling, which is critical for the regulation of organ size and tumorigenesis. Here, we discover that the suppression of the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C2175-.5MG | 04061832676302 |
| C2175-1MG | 04061833475270 |
| C2175-5MG | 04061832676326 |
| C2175-250UG | 04061832676319 |
| 79849-50MG | 04061832966588 |
| 79849-10MG | 04061832386027 |