Skip to Content
Merck

Key Documents

View All Documentation

Skip To

78830

Phenylmethanesulfonyl fluoride

≥99.0% (T)

Synonym(s):

α-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, PMSF, Phenylmethylsulfonyl fluoride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice

About This Item

Empirical Formula (Hill Notation):
C7H7FO2S
CAS Number:
329-98-6
Molecular Weight:
174.19
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
57652759
EC Number:
206-350-2
Beilstein/REAXYS Number:
2088311
MDL number:
MFCD00007424
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

synthetic

Quality Level

200

assay

≥99.0% (T)

form

powder or crystals

impurities

≤0.2% water

mp

92-95 °C

solubility

anhydrous isopropanol: soluble 35 mg/mL, clear to faintly hazy, colorless to faintly yellow (Heating required)

storage temp.

room temp

SMILES string

FS(=O)(=O)Cc1ccccc1

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

InChI key

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Application

Phenylmethanesulfonyl fluoride has been used as a component in radioimmunoprecipitation buffer for western blot analysis. It has also been used as a component in the RAW264.7 cell lysis buffer for western blotting.

Biochem/physiol Actions

Phenylmethanesulfonyl fluoride has the ability to enhance the stability of plasma lipidome in lipidomic and metabolomic analysis. This serine protease inhibitor reduces the naloxone-precipitated withdrawal jumping behavior in morphine-dependent mice.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Specific trypsin and chymotrypsin inhibitor. Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.[1]
Specific trypsin and chymotrypsin inhibitor; Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.[1]

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
P76269348252332
Phenylmethanesulfonyl fluoride ≥99.0% (T)

Sigma-Aldrich

78830

Phenylmethanesulfonyl fluoride

Phenylmethanesulfonyl fluoride ≥98.5% (GC)

Sigma-Aldrich

P7626

Phenylmethanesulfonyl fluoride

Phenylmethanesulfonyl fluoride solution ~0.1 M in ethanol (T)

Sigma-Aldrich

93482

Phenylmethanesulfonyl fluoride solution

Phenylmethylsulfonyl Fluoride Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

Sigma-Aldrich

52332

Phenylmethylsulfonyl Fluoride

assay

≥99.0% (T)

assay

≥98.5% (GC)

assay

-

assay

≥99% (GC)

biological source

synthetic

biological source

synthetic

biological source

microbial, synthetic

biological source

-

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

form

powder or crystals

form

powder

form

liquid

form

crystalline solid

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

storage temp.

10-30°C

solubility

anhydrous isopropanol: soluble 35 mg/mL, clear to faintly hazy, colorless to faintly yellow (Heating required)

solubility

dry solvents (ethanol, methanol, and 2-propanol): 200 mM (Stock solution are stable for months at 4°C.), H2O: unstable

solubility

-

solubility

ethanol: soluble, isopropanol: soluble, methanol: soluble

Still not finding the right product?

Explore all of our products under Phenylmethanesulfonyl fluoride

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

hcodes

H301,H314

Hazard Classifications

Acute Tox. 3 Oral - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCP7045
BCCN2101
BCCM0138
BCCL4547
BCCL1295

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Related Content

beta-catenin dosage is a critical determinant of tracheal basal cell fate determination
Brechbuhl H M, et al.
The American Journal of Pathology, 179(1), 367-379 (2011)
Q S Wang et al.
Acta pharmacologica Sinica, 22(3), 249-252 (2001-12-18)
To study the effect of phenylmethylsulfonyl fluoride (PMSF), a phospholipase C inhibitor, on ischemic injury to brain mitochondria in rats. The phospholipid level, membrane fluidity, and respiratory control ratio of brain mitochondria were measured. The effect of phenylmethylsulfonyl fluoride was
D.E. Fahrney et al.
Journal of the American Chemical Society, 85, 997-997 (1963)
View All Related Papers

Global Trade Item Number

SKUGTIN
78830-25G04061832947327
78830-5G04061835515257
78830-1G04061832947310

Questions

Reviews

No rating value

Active Filters