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30070

Cysteamine

≥98.0% (RT)

Synonym(s):

β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, MEA, Thioethanolamine

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About This Item

Linear Formula:
NH2CH2CH2SH
CAS Number:
Molecular Weight:
77.15
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-463-0
Beilstein/REAXYS Number:
635649
MDL number:
Assay:
≥98.0% (RT)
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Quality Level

assay

≥98.0% (RT)

storage temp.

2-8°C

SMILES string

NCCS

InChI

1S/C2H7NS/c3-1-2-4/h4H,1-3H2

InChI key

UFULAYFCSOUIOV-UHFFFAOYSA-N

Application

Cysteamine is suitable for use:
  • in the preparation of cysteamine modified gold nanoparticles (AuNP)[1]
  • in the fabrication of SU-8 microrods, where in, the amine group of cysteamine reacts with the unreacted epoxide rings present on the surface of the particles, thereby opening it and forming a covalent bond
  • to enhance in vitro development of porcine oocytes matured and fertilized in vitro[2]
  • in a study to demonstrate the depletion effect of cysteamine on cystinotic leucocyte granular fractions of cystine by disulphide interchange[3]
  • as a radioprotector[4]
  • to administer subcutaneously in rats to study its blocking effect on somatostatin secretion without modifying the pancreatic insulin or glucagon content [5]
  • as a scavenger in electrophoretic gels (acetic acid/urea gels)[6]

Biochem/physiol Actions

Cysteamine (β-mercaptoethylamine) depletes cystine from patient′s cells and there by regulates renal glomerular function and increases growth in them. Therefore, cysteamine is considered to be a potential therapeutic for nephropathic cystinosis.

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This Item
M97683008015014
assay

≥98.0% (RT)

assay

~95%

assay

≥97.0% (RT)

assay

≥99%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-


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signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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W A Gahl et al.
The Biochemical journal, 228(3), 545-550 (1985-06-15)
Cystinotic lysosome-rich leucocyte granular fractions, loaded with [35S]cystine, were exposed to different cystine-depleting agents. During a 30 min incubation at 37 degrees C, untreated cystinotic granular fractions lost negligible [35S]cystine when corrected for lysosome rupture. Granular fractions exposed to 0.1
Successful treatment of severe paracetamol overdosage with cysteamine.
L F Prescott et al.
Lancet (London, England), 1(7858), 588-592 (1974-04-06)
M J Barratt et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(11), 4781-4785 (1994-05-24)
Diverse agents, including growth factors and phorbol esters, induce rapid transcriptional activation of a subset of immediate-early (IE) genes that include the protooncogenes c-fos and c-jun. Among the earliest nuclear signaling events concomitant with IE gene activation is the phosphorylation



Global Trade Item Number

SKUGTIN
30070-10G04061826659397
30070-50G04061826659403

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    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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