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Cyclobenzaprine hydrochloride

Name: Cyclobenzaprine hydrochloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

5-(3-Dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₁N · HCl

CAS Number:

6202-23-9

Molecular Weight:

311.85

NACRES:

NA.24

PubChem Substance ID:

329775025

UNSPSC Code:

41116107

MDL number:

MFCD00079039

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Properties

grade

pharmaceutical primary standard

API family

cyclobenzaprine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CN(C)CC\C=C1\c2ccccc2C=Cc3ccccc13

InChI

1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H

InChI key

VXEAYBOGHINOKW-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356), HTR2C(3358)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cyclobenzaprine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Skeletal muscle relaxant; 5-HT₂ serotonin receptor antagonist.

Skeletal muscle relaxant; reduces muscle spasm by depression of brainstem neurons; 5-HT₂ serotonin receptor antagonist.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	BP886	1154503	PHR2797
C3200000 Cyclobenzaprine hydrochloride	BP886 Cyclobenzaprine hydrochloride	USP 1154503 Cyclobenzaprine hydrochloride	Supelco PHR2797 Cyclobenzaprine Hydrochloride
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade -	grade certified reference material, pharmaceutical secondary standard
manufacturer/tradename EDQM	manufacturer/tradename BP	manufacturer/tradename USP	manufacturer/tradename -
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical small molecule
format neat	format neat	format -	format -
API family cyclobenzaprine	API family cyclobenzaprine	API family cyclobenzaprine	API family cyclobenzaprine
Gene Information human ... HTR2A(3356), HTR2C(3358)	Gene Information human ... HTR2A(3356), HTR2C(3358)	Gene Information -	Gene Information -

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pictograms

GHS06

signalword

Danger

hcodes

H301,H312 + H332

pcodes

P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study.

Harvey Moldofsky et al.

The Journal of rheumatology, 38(12), 2653-2663 (2011-09-03)

To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the α-nonREM sleep electroencephalographic (EEG) anomaly at screening. Of 37 patients with FM in the

Determination of cyclobenzaprine in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study.

Yi Xiang et al.

Biomedical chromatography : BMC, 26(9), 1083-1088 (2011-11-29)

A sensitive, rapid and simple liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS/MS) method was developed for the quantitative determination of cyclobenzaprine in human plasma, to study the pharmacokinetic behavior of cyclobenzaprine capsule in healthy Chinese volunteers. With escitalopram as the internal

Chlorpromazine quantification in human plasma by UPLC-electrospray ionization tandem mass spectrometry. Application to a comparative pharmacokinetic study.

Ney Carter Borges et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(31), 3728-3734 (2011-11-15)

In the present study a method to quantify chlorpromazine in human plasma using cyclobenzaprine as the internal standard (IS) is described. The analyte and the IS were extracted from human plasma by a liquid-liquid extraction with diethyl ether/dichloromethane (70/30, v/v)

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Global Trade Item Number

SKU	GTIN
C3200000	04061833485569

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