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42147

(RS)-Mevalonic acid lithium salt

analytical standard

Synonym(s):

(±)-MVA-Li, rac.-MVA-Li, Lithium (±)-3,5-dihydroxy-3-methyl-pentanoate, Lithium (±)-3,5-dihydroxy-3-methyl-valerate

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About This Item

Empirical Formula (Hill Notation):
C6H11O4 · xLi+
CAS Number:
Molecular Weight:
147.15 (free acid basis)
MDL number:
UNSPSC Code:
85151701
NACRES:
NA.24
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grade

analytical standard

Quality Level

assay

≥96.0% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

SMILES string

OC(CCO)(CC(=O)O)C

InChI

1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)

InChI key

KJTLQQUUPVSXIM-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

NMR-Internal standard: Dimethylsulfone

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43987D363590469
grade

analytical standard

grade

analytical standard

grade

analytical standard

grade

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

assay

≥96.0% (GC)

assay

≥97.0% (GC)

assay

-

assay

≥96.0% (GC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

format

neat

format

neat

format

neat

format

-


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Andréa Hemmerlin
Plant science : an international journal of experimental plant biology, 203-204, 41-54 (2013-02-19)
Identification of regulatory enzymes is fundamental for engineering metabolic pathways such as the isoprenoid one. All too often, investigation of gene expression remains the major trend in unraveling regulation mechanisms of the isoprenoid cytosolic mevalonate and the plastid-localized methylerythritol phosphate
Elena Lesma et al.
The Journal of pharmacology and experimental therapeutics, 345(2), 180-188 (2013-02-22)
Tuberous sclerosis complex (TSC) is a multi-systemic syndrome caused by mutations in TSC1 or TSC2 gene. In TSC2-null cells, Rheb, a member of the Ras family of GTPases, is constitutively activated. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase and block the
Ai Hosaka et al.
Neurochemical research, 38(3), 589-600 (2012-12-28)
Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been reported to attenuate amyloid-β peptide (Aβ) production in various cellular models. However, the mechanisms by which statins affect neuronal Aβ production have not yet been clarified. Here, we investigated this issue in



Global Trade Item Number

SKUGTIN
208965-25G04061838770370
42147-5MG04061832093888

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