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34044

Tiamulin

VETRANAL®, analytical standard

Synonym(s):

(1S,2R,3S,4S,6R,7S,14R)-6-[(2-Diethylaminoethylthio)acetoxy]-3-hydroxy-2,4,7,14-tetramethyl-4-vinyltricyclo[5,4,3,01.8]tetradecan-9-one

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About This Item

Empirical Formula (Hill Notation):
C28H47NO4S
CAS Number:
Molecular Weight:
493.74
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
259-580-0
NACRES:
NA.24
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grade

analytical standard

Quality Segment

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)C1(C)[C@@H]2C(=O)CC3

InChI

1S/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19-,20+,22-,24+,25+,26-,27+,28+/m1/s1

InChI key

UURAUHCOJAIIRQ-QGLSALSOSA-N

General description

Tiamulinis a veterinary drug with very low water solubility (0.000524 mg/mL). Its mode of action involves suppressing protein synthesis in bacteria.
Chemical structure: macrolide

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
For detailed application information, please see the Frequently Asked Questions (FAQ) section at the bottom of this page.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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grade

analytical standard

grade

-

grade

pharmaceutical primary standard

grade

analytical standard

format

neat

format

-

format

neat

format

neat

mode of action

enzyme | inhibits

mode of action

protein synthesis | interferes

mode of action

-

mode of action

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

clinical testing

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

limited shelf life, expiry date on the label


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hcodes

Hazard Classifications

Aquatic Chronic 4

Storage Class

10 - Combustible liquids

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)



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"Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin?
Schlunzen F, et al.
Molecular Microbiology, 54(05), 1287-1294 (2004)
K M S Islam et al.
Poultry science, 87(12), 2528-2534 (2008-11-29)
In an earlier study, the continuous medication of broiler feed with a combination of tiamulin (TIA; 20 mg/kg), chlortetracycline (CTC; 60 mg/kg), and the ionophore anticoccidial salinomycin (SAL; 60 mg/kg) caused an initial increase in BW and feed efficiency (FE;
Decreased susceptibility of MRSA ST398 to tiamulin.
Joseph E Rubin et al.
Veterinary microbiology, 151(3-4), 422-423 (2011-04-23)



Global Trade Item Number

SKUGTIN
34044-100MG-R04061826753132

Questions

1–2 of 2 Questions  
  1. What is the best way to remove a portion of the material from the vial, in order to prepare a standard from Product 34044, Tiamulin?

    1 answer
    1. Tiamulin is a viscous liquid at room temperature, so it is a little difficult to work with. The kind of vial that is used for Product 34044-100MG-R is what Sigma-Aldrich Germany typically uses for amounts of about 10 mg to 100 mg. Tiamulin does not have a good chromophore, so we don't have an extinction coefficient for it; that is, if there were a chromophore, one might be able to quantitate it by measuring the UV absorbance of a solution.Here are our recommendations:1. Heat the vial up to 50-60°C. This will significantly reduce the viscosity of the Tiamulin.2. If there is material visible in the cap of the vial, spin it down using a small benchtop centrifuge for a few seconds. Briefly warm back up to 50-60°C if the vial cools down significantly during centrifugation.3. Using a pipetter, carefully transfer about 10 microliters of the warm liquid into a tared vial on a balance.4. Obtain an accurate weight, and use that in your calculations.As the material is needed, the vial can be heated several times to 50-60°C, without harming it. The 100 mg is roughly 100 microliters, so following the recommendations above, you should be able to obtain about 10 samples from the vial of 34044-100MG-R.

      Helpful?

  2. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

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